Systems and methods for ion separation

Patent metadata

Field	Value
Publication number	US-9607817-B1
Application number	US-201514852294-A
Country	US
Kind code	B1
Filing date	Sep 11, 2015
Priority date	Sep 11, 2015
Publication date	Mar 28, 2017
Grant date	Mar 28, 2017

Abstract

A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separation device, a plurality of ion channels, and a mass analyzer configured to determine the mass-to-charge ratio of the ions. The mobility device is configured to separate ions received from the source based on the mobility in a gas. The mobility separation device provides a gas flow in a first direction and an electric field gradient along a second direction such that ions move in the first direction and drift according to their mobility in the second direction and are sorted based on their respective mobility. The ion channels are arranged adjacent to the mobility separation device such that ions from the mobility separation device are directed to different channels according to their respective mobility.

First claim

What is claimed is:

1. A system for analyzing a sample comprising:
a source configured to generate ions from constituent components of the sample;
a mobility separator configured to separate ions received from the source based on the mobility in a gas; the mobility separator providing a gas flow in a first direction and an electric field gradient along a second direction such that ions move in the first direction and drift according to their mobility in the second direction such that the ions are sorted based on their respective mobility;
a plurality of ion channels arranged adjacent to the mobility separator such that ions from the mobility separator are directed to different channels according to their respective mobility; and
a mass analyzer configured to determine the mass-to-charge ratio of the ions.

2. The system of claim 1 , wherein an angle between the first direction and the second direction is between about 45° and about 135°.

3. The system of claim 2 , wherein the first direction and the second direction are orthogonal.

4. The system of claim 1 , wherein the ion channels are selected from the group consisting of RF ion guides, ion traps, DC ion lenses, and a combination thereof.

5. The system of claim 1 further comprising a transfer guide configured to transport ions from the plurality of ion channel to a mass analyzer.

6. The system of claim 1 , wherein each ion channels is defined by a plurality of rods.

7. The system of claim 6 , wherein each ion channels has one or more drag vanes.

8. The system of claim 7 , wherein the plurality of ion channels comprise:
a plurality of guide rod pairs, individual guide rods extending along an ion channel length, guides rods of a guide rod pair separated in a first separation direction orthogonal to the ion channel length, and the pairs of guide rods separated in a second separation direction orthogonal to the ion channel length and the first separation direction, such that adjacent ion channel share a guide rod pair located between the adjacent ion channels; and
a plurality of drag vane pairs arranged such that individual drag vane pairs are positioned between adjacent guide rod pairs along the second separation direction such that individual ion channels have unique drag vane pairs.

9. The system of claim 1 , wherein the plurality of ion channels includes between about 3 ion channels and about 50 ion channels.

10. The system of claim 9 , wherein the plurality of ion channels includes between about 5 ion channels and about 20 ion channels.

11. The system of claim 10 , wherein the plurality of ion channels includes between about 7 ion channels and about 15 ion channels.

12. The system of claim 1 , wherein the electric field gradient is a substantially uniform electric field gradient.

13. The system of claim 1 , wherein the electric field gradient is a non-uniform electric field gradient.

14. The system of claim 1 , wherein a gas pressure within the mobility separator is between about 1 Torr to about 20 Torr.

15. The system of claim 14 , wherein the gas pressure within the mobility separator is between about 3 Torr to about 6 Torr.

16. The system of claim 1 , wherein a gas flow within the mobility separator is between about 15 slm and about 30 slm.

17. The system of claim 1 , wherein a gas velocity within the mobility separator is between about 100 m/s and about 300 m/s.

18. The system of claim 17 , wherein the gas velocity within the mobility separator is between about 150 m/s and about 200 m/s.

19. The system of claim 1 further comprising a lens array positioned between the mobility separator and the plurality of ion channels, the lens array configured to guide ions into respective ion channels.

20. An ion mobility device for separating ions based on their ion mobility, comprising:
a mobility cell having a gas inlet and a gas outlet opposite the inlet along a first direction such that a gas flow introduced at the gas inlet would flow in a first direction to the gas outlet, an ion entrance and a plurality of ion exit orifices opposite the ion entrance along a second direction and offset from the ion entrance and spaced apart from one another along the first direction,
a plurality of electrodes configured to generate an electric field gradient in the second direction such that ions entering the mobility cell flow in the first direction with the gas and drift according to their mobility in the gas in the second direction; and
a plurality of ion channels arranged parallel to one another and arranged adjacent to the mobility cell at the plurality of ion exit orifices, the ion channels configured to receive ions from the mobility cell such that ions entering an individual channel have a range of ion mobilities that is different from a range of ion mobilities for ions entering an adjacent ion channel.

21. The ion mobility device of claim 20 , wherein the ion channels are selected from the group consisting of RF ion traps, ion guides, DC ion lenses, and combination thereof.

22. The ion mobility device of claim 20 , wherein the electric field gradient is generated by a series of discrete electrodes, one or more continuous resistive elements, or a combination thereof.

23. The ion mobility device of claim 20 further comprising a lens array positioned between the ion exit orifices and the plurality of ion channels, the lens array configured to guide ions into respective ion channels.

24. A method for identifying components of a sample comprising:
providing a sample to an ion source and generating a plurality of ions from constituent components of the sample;
directing the ions into a mobility separator having a gas flow in a first direction and an electric field gradient along a second direction such that the ions move in the first direction and drift according to their mobility in the second direction;
separating the ions into a plurality of ion channels such that ions entering an individual ion channel have a range of ion mobilities that is different from a range of ion mobilities for ions entering an adjacent ion channel;
directing ions from individual ion channels into a mass analyzer; and
using the mass analyzer to determine the mass-to-charge ratio of the ions.

25. The method of claim 24 , wherein a gas flow within the mobility separator is between about 15 slm and about 30 slm.

26. The method of claim 24 , wherein a gas velocity within the mobility separator is between about 100 m/s and about 300 m/s.

27. The method of claim 24 , wherein an angle between the first direction and the second direction is between about 45° and about 135°.

28. The method of claim 27 , wherein the first direction and the second direction are orthogonal.

29. The method of claim 24 , wherein the plurality of ion channels comprise:
a plurality of guide rod pairs, individual guide rods extending along an ion channel length, guides rods of a guide rod pair separated in a first separation direction orthogonal to the ion channel length, and the pairs of guide rods separated in a second separation direction orthogonal to the ion channel length and the first separation direction, such that adjacent ion channels share a guide rod pair located between the adjacent ion channels; and
a plurality of drag vane pairs arranged such that individual drag vane pairs are positioned between adjacent guide rod pairs along t

Assignees

• Thermo Finnigan Llc

Inventors

• Ugarov Mikhail V

Classifications

• H01J49/04 Primary

  Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components · CPC title

• H01J49/426

  Methods for controlling ions · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/10 Primary

  Ion sources; Ion guns · CPC title

• H01J49/0009

  Calibration of the apparatus · CPC title