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Compounds for inflammation and immune-related uses
US9604978B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9604978-B2 |
| Application number | US-201214115506-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 3, 2012 |
| Priority date | May 3, 2011 |
| Publication date | Mar 28, 2017 |
| Grant date | Mar 28, 2017 |
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- Title
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- Abstract
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- Assignees and inventors
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- Key dates
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- First independent claim
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- CPC / IPC classifications
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- Citations and related patents
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Abstract
Official abstract text for this publication.
The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound selected from the group consisting of: Number Structure Compound Name 1. N-(5-(2-chloro-5-( 1 H-pyrazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide 2. N-(5-(2-ethoxy-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide 3. N-(5-(2-chloro-5-(2-methylthiazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide 6. 5-fluoro-N-(5-(2-methoxy-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin- 2-yl)-4-methylnicotinamide 8. N-(5-(2-ethyl-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide 14. N-(5-(2-chloro-5-(5-methylthiazol-2- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide 16. N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide 19. N-(5-(2-isopropoxy-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide 22. 5-fluoro-4-methyl-N-(5-(5-(1-methyl- 1 H-pyrazol-4-yl)-2- (trifluoromethoxy)phenyl)pyrazin- 2-yl)nicotinamide 24. N-(5-(2-chloro-5-(3-fluoropyridin- 4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide 26. N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)- 5-fluoro-4-methylnicotinamide 27. N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)- 5-fluoro-4-methylnicotinamide 34. N-(5-(2-chloro-5-((6- (trifluoromethyl)pyridin-2- yl)oxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide 36. N-(5-(5-((3-fluoropyridin-2- yl)oxy)-2-methylphenyl)pyrazin- 2-yl)-4-methylnicotinamide 38. N-(5-(5-((3-fluoropyridin-2-yl)oxy)-2- (trifluoromethoxy)phenyl)pyrazin- 2-yl)-4-methylnicotinamide 39. N-(5-(2-cyano-5-(oxetan-3- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide 44. 4-methyl-N-(5-(2-methyl-5-(pyridin- 3-ylethynyl)phenyl)pyrazin-2- yl)nicotinamide 45. 4-methyl-N-(5-(2-methyl-5-(2-methyl- 2H-tetrazol-5-yl)phenyl)pyrazin- 2-yl)nicotinamide 49.
Assignees
Inventors
Classifications
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title
Immunomodulators · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9604978B2 cover?
- The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
- Who is the assignee on this patent?
- Chen Shoujun, Bohnert Gary, Jiang Jun, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07D417/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 28 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).