Preparation of haloalkoxyarylhydrazines and intermediates therefrom

Patent metadata

Field	Value
Publication number	US-9604942-B2
Application number	US-201514725276-A
Country	US
Kind code	B2
Filing date	May 29, 2015
Priority date	Mar 13, 2013
Publication date	Mar 28, 2017
Grant date	Mar 28, 2017

Abstract

The invention in this document is related to the field of preparation of haloalkoxyarylhydrazines and certain intermediates derived therefrom, where said intermediates are useful in the preparation of certain pesticides disclosed in U.S. Pat. No. 8,178,658.

First claim

What is claimed is:

1. A process for preparing a compound of the formula 3.2

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl comprising the step of contacting a compound of the formula 2.1

with an anhydrous inorganic acid in the presence of a polar, protic solvent to provide an imidate salt of the formula 2.2

wherein R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl;
R 2 is (C 1 -C 6 )alkyl; and
X ⊖ is a counter ion of an inorganic acid.

2. The process of claim 1 for preparing a compound of the formula 3.2

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl, further comprising the step of contacting the imidate salt of the formula 2.2

wherein R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl;
R 2 is (C 1 -C 6 )alkyl; and
X 63 is a counter ion of an inorganic acid,

with a compound of the formula 1.2

or a salt thereof, wherein R is a (C 1 -C 6 )haloalkoxy, in the presence of a weakly alkaline, heterocyclic solvent, or a non-basic, polar, aprotic solvent and a base, to provide an iminohydrazine compound of the formula 3.1

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl.

3. The process of claim 2 for preparing a compound of the formula 3.2

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 C 6 )alkyl, further comprising the step of contacting the iminohydrazine compound of the formula 3.1

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl, with a formate source to provide a compound of the formula 3.2

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl.

4. The process of claim 1 , wherein the anhydrous inorganic acid is selected from the group consisting of HF, HCl, HBr and HI.

5. The process of claim 4 , wherein the anhydrous inorganic acid is HCl or HBr.

6. The process of claim 5 , wherein the polar, protic solvent is an alcohol solvent.

7. The process of claim 6 , wherein the alcohol solvent is methanol, ethanol, n-butanol, iso-propanol, or a mixture thereof.

8. The process of claim 1 , wherein R 1 is —C(O)OMe.

9. The process of claim 1 , wherein R 1 is —C(O)OEt.

10. The process of claim 1 , wherein R 2 is methyl.

11. The process of claim 1 , wherein R 2 is ethyl.

12. The process of claim 1 , wherein the anhydrous inorganic acid of step (a) is generated in situ by contacting an acyl halide with an alcohol.

13. The process of claim 1 , wherein the anhydrous inorganic acid of step (a) is generated in situ by contacting thionyl chloride with an alcohol.

14. The process of claim 3 for preparing a compound of the formula 3.2further comprising the step of contacting a

wherein R is a (C 1 -C 6 )haloalkoxy, and R 1 is —NO 2 , —C(O)OH or —C(O)O(C 1 -C 6 )alkyl, further comprising the step of contacting a haloalkoxyaniline of Formula 1

with sodium nitrite to produce an intermediate diazonium salt of Formula 1.1

followed by reducing the intermediate diazonium salt of Formula 1.1 to produce a haloalkoxyarylhydrazine salt of Formula 1.2

wherein R is (C 1 -C 6 )haloalkoxy; and n is 0, 1, or 2.

15. The process of claim 14 , wherein the molar ratio of haloalkoxyanaline to sodium nitrite is from about 1:1 to about 1:2.

16. The process of claim 14 , wherein the step of contacting haloalkoxyanaline with sodium nitrite is carried out in a polar, protic solvent.

17. The process of claim 14 , wherein the step of contacting haloalkoxyanaline with sodium nitrite is carried out in the presence of an inorganic acid.

18. The process of claim 17 , wherein the inorganic acid the step of contacting haloalkoxyanaline with sodium nitrite is selected from the group consisting of HCl, HNO 3 , H 3 PO 4 , H 2 SO 4 , H 3 BO 3 , HF, HBr, HClO 4 and HBF 4 .

19. The process of claim 14 , wherein the pH of the step of contacting haloalkoxyanaline with sodium nitrite is about −1 to about 4.

20. The step of claim 14 , wherein the temperature of the step of contacting haloalkoxyanaline with sodium nitrite is about −10° C. to about 5° C.

Assignees

• Dow Agrosciences Llc

Inventors

• Ross Jr Ronald
• Roth Gary

Classifications

• C07D249/08 Primary

  1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles · CPC title

• C07C249/02

  of compounds containing imino groups · CPC title

• C07C243/22

  having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings · CPC title