Micro-fluidic chambers for use in liquid medicament delivery systems

Patent metadata

Field	Value
Publication number	US-9603998-B2
Application number	US-87756910-A
Country	US
Kind code	B2
Filing date	Sep 8, 2010
Priority date	Sep 11, 2009
Publication date	Mar 28, 2017
Grant date	Mar 28, 2017

Abstract

Micro-fluidic chambers for use in a liquid medicament delivery system, include a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the chamber, wherein, one or more walls or fillings are positioned in the chamber, the walls or fillings defining a fluid channel there between such that the fluid channel extends from an inlet of the chamber to an outlet of the chamber, wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the fluid chamber.

First claim

What is claimed:

1. A micro-fluidic chamber for use in a liquid medicament delivery system, the micro-fluidic chamber comprising:
a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the micro-fluidic chamber;
wherein, two or more walls or fillings are positioned in the micro-fluidic chamber, the walls or fillings forming a fluid channel between the walls or fillings, the fluid channel extending from an inlet conduit connected to an inlet of the micro-fluidic chamber to an outlet conduit connected to an outlet of the micro-fluidic chamber;
wherein, each of the walls or fillings has a height less than the height of the micro-fluidic chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and
wherein, the dimensions of the walls or fillings and the micro-fluidic chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the micro-fluidic chamber;
wherein, the top cover comprises a gas-permeable membrane which allows gas to freely pass through the gas-permeable membrane and prevents liquid from passing through the gas-permeable membrane.

2. The micro-fluidic chamber of claim 1 , wherein a height of the fluid gap is from 0.02 to 0.2 mm.

3. The micro-fluidic chamber of claim 2 , wherein a height of the fluid gap is from 0.05 and 0.15 mm.

4. The micro-fluidic chamber of claim 1 , wherein the top cover comprises a flexible membrane.

5. The micro-fluidic chamber of claim 1 , wherein at least one of a part of the surface of the bottom structure, the walls, and the top cover facing toward an inner volume of the micro-fluidic chamber is hydrophilic.

6. The micro-fluidic chamber of claim 1 , wherein the fluid channel comprises a meander-like shape.

7. The micro-fluidic chamber of claim 1 , wherein the fluid channel extends uninterrupted from the inlet conduit to the outlet conduit.

8. A pressure sensor for use in a liquid medicament delivery system, the pressure sensor comprising:
a rigid bottom structure and a top cover, the top cover comprising a flexible, resilient membrane being spaced from the rigid bottom structure so as to define a height of a chamber;
wherein, two or more walls or fillings are positioned in the chamber, the walls or fillings forming a fluid channel between the walls or fillings, the fluid channel extending from an inlet conduit connected to an inlet of the micro-fluidic chamber to an outlet conduit connected to an outlet of the micro-fluidic chamber;
wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover;
wherein, the top cover comprises a gas-permeable membrane which allows gas to freely pass through the gas-permeable membrane and prevents liquid from passing through the gas-permeable membrane;
wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the chamber; and
wherein, when there is no pressure difference between an external pressure of the chamber and an internal pressure of the chamber, the top cover remains flat and when the external pressure of the chamber is less than the internal pressure, the top cover bulges outwards.

9. The pressure sensor of claim 8 wherein, wherein a height of the fluid gap is from 0.02 to 0.2 mm.

10. The pressure sensor of claim 9 wherein, wherein a height of the fluid gap is from 0.05 and 0.15 mm.

11. The pressure sensor of claim 8 wherein, a detection system is arranged to measure a deformation of the top cover of the chamber.

12. The pressure sensor of claim 8 wherein, wherein at least one of a part of the surface of the rigid bottom structure, the walls, and the top cover facing toward an inner volume of the micro-fluidic chamber is hydrophilic.

13. The pressure sensor of claim 8 , wherein the fluid channel comprises a meander-like shape.

14. The pressure sensor of claim 8 , wherein the fluid channel extends uninterrupted from the inlet conduit to the outlet conduit.

Assignees

• Geipel Andreas
• Huwiler Christoph
• Kühni Florian
• Roche Diagnostics Int Ag

Inventors

• Geipel Andreas
• Huwiler Christoph
• Kühni Florian

Classifications

• G01R33/302

  Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips · CPC title

• Y10T137/8593

  Systems · CPC title

• A61M2205/0244

  Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology · CPC title

• Y10T137/8326

  Fluid pressure responsive indicator, recorder or alarm · CPC title

• A61M5/16877 Primary

  Adjusting flow; Devices for setting a flow rate · CPC title