Bioerodible polymer compositions

Patent metadata

Field	Value
Publication number	US-9603975-B2
Application number	US-201514971430-A
Country	US
Kind code	B2
Filing date	Dec 16, 2015
Priority date	Dec 16, 2014
Publication date	Mar 28, 2017
Grant date	Mar 28, 2017

Abstract

The present disclosure pertains to compositions that comprise (a) a bioerodible polyester network formed by reaction between reactive species that comprise a polyol and a polycarboxylate, wherein at least one of the polyol and polycarboxylate has a functionality of three or more, and (b) a bioerodible thermoplastic polymer. The present disclosure further pertains to methods of using such compositions and to medical devices that comprise such compositions.

First claim

What is claimed is:

1. A composition comprising (a) a bioerodible polyester network formed by reaction between reactive species that comprise a polyol and a polycarboxylate, wherein at least one of the polyol and polycarboxylate has a functionality of three or more, and (b) a bioerodible thermoplastic polymer with a melting point above body temperature.

2. The composition of claim 1 , wherein the polyol is selected from a non-polymeric diol, a polymeric diol, a non-polymeric triol, a polymeric triol, and wherein the polycarboxylate is selected from a non-polymeric dicarboxylate, a polymeric dicarboxylate, a non-polymeric tricarboxylate, and a polymeric tricarboxylate.

3. The composition of claim 1 , wherein the reactive species comprise a triol, a tricarboxylate, or both.

4. The composition of claim 1 , wherein the reactive species comprise (a) non-polymeric tricarboxylate and (b) a polyester polyol.

5. The composition of claim 1 , wherein the reactive species comprise (a) citric acid and (b) a polycaprolactone diol, a polycaprolactone triol or both.

6. The composition of claim 1 , wherein the bioerodible thermoplastic polymer has a glass transition temperature below room temperature.

7. The composition of claim 1 , wherein the bioerodible thermoplastic polymer is a bioerodible thermoplastic polyester.

8. The composition of claim 1 , wherein the composition is a solid composition.

9. The composition of claim 8 , wherein the bioerodible polyester network is not covalently linked to the bioerodible thermoplastic polymer.

10. The composition of claim 9 , wherein the bioerodible thermoplastic polymer is not covalently linked to itself or wherein the bioerodible thermoplastic polymer is covalently linked to itself.

11. The composition of claim 1 , wherein the composition is a liquid composition and further comprises a solvent within which the bioerodible polyester network and the bioerodible thermoplastic polymer are dissolved or dispersed, wherein the bioerodible polyester network is a partially crosslinked bioerodible polyester network.

12. The composition of claim 11 , wherein the bioerodible thermoplastic polymer is end capped with unsaturated groups and wherein the liquid composition further comprises a free radical initiator.

13. A method comprising (a) applying to a substrate a liquid composition comprising (i) a partially crosslinked bioerodible polyester network formed by reaction between reactive species that comprise a polyol and a polycarboxylate, wherein at least one of the polyol and polycarboxylate has a functionality of three or more, (ii) a bioerodible thermoplastic polymer and (iii) a solvent within which the partially crosslinked bioerodible polyester network and the bioerodible thermoplastic polymer are dissolved or dispersed and (b) heating the composition to further crosslink the partially crosslinked bioerodible polyester network.

14. The method of claim 13 , wherein the substrate is a medical device substrate and wherein the liquid composition is applied as a coating or covering to the substrate.

15. The method of claim 13 , wherein the bioerodible thermoplastic polymer comprises unsaturated groups and wherein the liquid composition comprises a free radical initiator that crosslinks the unsaturated groups as a result of the heating or that crosslinks the unsaturated groups upon application of ultraviolet light.

16. A method comprising (a) applying to a substrate a liquid composition comprising (i) a partially crosslinked biocompatible polyester network formed by reaction between reactive species that comprise a polyol and a polycarboxylate, wherein at least one of the polyol and polycarboxylate has a functionality of three or more, (ii) a biocompatible thermoplastic polymer and (iii) a solvent within which the partially crosslinked biocompatible polyester network and the biocompatible thermoplastic polymer are dissolved or dispersed and (b) heating the composition to further crosslink the partially crosslinked biocompatible polyester network.

17. The method of claim 16 , wherein the substrate is a medical device substrate and wherein the liquid composition is applied as a coating or covering to the substrate.

18. The method of claim 16 , wherein the biocompatible thermoplastic polymer comprises unsaturated groups and wherein the liquid composition comprises a free radical initiator that crosslinks the unsaturated groups as a result of the heating or that crosslinks the unsaturated groups upon application of ultraviolet light.

19. A method comprising (a) applying to a substrate a liquid composition comprising (i) a partially crosslinked bioerodible polyester network formed by reaction between reactive species that comprise a polyol and a polycarboxylate, wherein at least one of the polyol and polycarboxylate has a functionality of three or more, (ii) a biocompatible thermoplastic polymer and (iii) a solvent within which the partially crosslinked bioerodible polyester network and the biocompatible thermoplastic polymer are dissolved or dispersed and (b) heating the composition to further crosslink the partially crosslinked bioerodible polyester network.

20. The method of claim 19 , wherein the substrate is a medical device substrate and wherein the liquid composition is applied as a coating or covering to the substrate.

Assignees

• Boston Scient Scimed Inc

Inventors

• Fredrickson Gerald
• Sinisi Michael David

Classifications

• C08L101/16

  the macromolecular compounds being biodegradable · CPC title

• C08L71/02

  Polyalkylene oxides · CPC title

• A61L31/041 Primary

  Mixtures of macromolecular compounds · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• C08L67/00

  Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain (of polyester-amides C08L77/12; of polyester-imides C08L79/08); Compositions of derivatives of such polymers · CPC title