Process for treating sol-gel capsules

Patent metadata

Field	Value
Publication number	US-9603784-B2
Application number	US-201113818307-A
Country	US
Kind code	B2
Filing date	Sep 1, 2011
Priority date	Sep 30, 2010
Publication date	Mar 28, 2017
Grant date	Mar 28, 2017

Abstract

The present invention relates to a process for treating sol-gel capsules comprising a cosmetic or pharmaceutical active material with an inorganic material, as well as sol-gel capsules produced by a process according to the present invention and formulations comprising such sol-gel capsules.

First claim

The invention claimed is:

1. A process for treating sol-gel capsules comprising an encapsulated cosmetic or pharmaceutical active material with an inorganic material, said process comprising the following steps
a) providing a suspension of sol-gel capsules,
b) adding one or more water-soluble inorganic precursor compounds,
c) precipitating the inorganic material onto the capsules' surfaces,
d) optionally repeating steps b) and c) one or more times, and
e) optionally isolating and/or drying the treated sol-gel capsules.

2. The process of claim 1 , wherein the sol-gel capsules are silica capsules.

3. The process of claim 1 , wherein the inorganic material is selected from the group consisting of SiO 2 , TiO 2 , ZnO and SnO 2 .

4. The process of claim 1 , wherein the one or more inorganic precursor compounds of step b) are selected from the group consisting of Na 2 SiO 3 , TiCl 4 , ZnCl 2 and SnCl 4 .

5. The process of claim 1 , wherein in step b) an acid or base is added.

6. The process of claim 1 , wherein the temperature of step b) and c) are between 30 and 120° C.

7. The process of claim 1 , wherein the pH of step c) is between 1 and 9.

8. The process of claim 1 , wherein the sol-gel capsules are first treated with SiO 2 , followed by the treatment with SnO 2 and/ or followed by the treatment with TiO 2 .

9. The process of claim 1 , wherein the encapsulated cosmetic or pharmaceutical active material comprises one or more UV filters.

10. The process of claim 9 , wherein the one or more UV filters are one or more of 3-(4′-methylbenzylidene)-dl-camphor, 1-(4- tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 4-isopropyl-dibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyl methoxycinnamate, 3,3,5-trimethylcyclohexyl salicylate, 2-ethylhexyl 4-(dimethylamino)benzoate, 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, or 2-phenylbenzimidazole-5-sulfonic acid or a the potassium, sodium or triethanolamine salt thereof.

11. The process of claim 1 , wherein the sol-gel capsules in step a) are obtained in a process that comprises the following steps
a1) preparing an oil-in-water emulsion of a hydrophobic solution comprising the sol-gel precursor and at least one cosmetic or pharmaceutical active material in an aqueous solution,
b1) mixing the emulsion from step) with another aqueous solution in order to accelerate the condensation polymerisation reaction,
optionally c1) separating off reaction products from the sol-gel precursor, and isolating the sol-gel capsules.

12. A sol-gel capsule comprising an encapsulated cosmetic or pharmaceutical active material produced by a process, which comprises the following steps
a) providing a suspension of sol-gel capsules,
b) adding one or more water-soluble inorganic precursor compounds,
c) precipitating the inorganic material onto the capsules' surfaces,
d) optionally repeating steps b) and c) one or more times, and
e) optionally isolating and/or drying the treated sol-gel capsules.

13. A formulation comprising sol-gel capsules of claim 12 and at least one other ingredient.

14. A formulation of claim 13 , which comprises 5 to 80% by weight of sol-gel capsules.

15. A process for the preparation of a formulation, comprising mixing the sol-gel capsules of claim 12 with further ingredients.

16. A sol-gel capsule according to claim 12 , which are silica capsules.

17. A sol-gel capsule according to claim 12 , wherein the inorganic material is selected from the group consisting of SiO 2 , TiO 2 , ZnO and SnO 2 .

18. A sol-gel capsule according to claim 12 , wherein the one or more inorganic precursor compounds of step b) are selected from the group consisting of Na 2 SiO 3 , TiCl 4 , ZnCl 2 and SnCl 4 .

19. A sol-gel capsule according to claim 12 , wherein the sol-gel capsules are first treated with SiO 2 , followed by the treatment with SnO 2 and/ or followed by the treatment with TiO 2 .

20. A sol-gel capsule according to claim 12 , wherein the encapsulated cosmetic or pharmaceutical active material comprises one or more UV filters.

21. A sol-gel capsule according to claim 12 , produced by a process that consists essentially of the following steps
a) providing a suspension of sol-gel capsules,
b) adding one or more water-soluble inorganic precursor compounds,
c) precipitating the inorganic material onto the capsules' surfaces,
d) optionally repeating steps b) and c) one or more times, and
e) optionally isolating and/or drying the treated sol-gel capsules.

22. A sol-gel capsule according to claim 12 , produced by a process that consists of the following steps
a) providing a suspension of sol-gel capsules,
b) adding one or more water-soluble inorganic precursor compounds,
c) precipitating the inorganic material onto the capsules' surfaces,
d) optionally repeating steps b) and c) one or more times, and
e) optionally isolating and/or drying the treated sol-gel capsules.

Assignees

• Shimizu Kaiman
• Watanabe Yukitaka
• Kubota Yuichi
• Sasaki Fumiko
• Kawagoe Keisuke
• Witte Gabriele
• Pfluecker Frank
• Merck Patent Gmbh

Inventors

• Shimizu Kaiman
• Watanabe Yukitaka
• Kubota Yuichi
• Sasaki Fumiko
• Kawagoe Keisuke
• Witte Gabriele
• Pfluecker Frank

Classifications

• A61K2800/412

  Microsized, i.e. having sizes between 0.1 and 100 microns · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• C09C1/3054

  Coating · CPC title

• C01P2004/61

  Micrometer sized, i.e. from 1-100 micrometer · CPC title

• C01P2004/86

  Thin layer coatings, i.e. the coating thickness being less than 0.1 time the particle radius · CPC title