Automatic analyzer

Patent metadata

Field	Value
Publication number	US-9599631-B2
Application number	US-201214239379-A
Country	US
Kind code	B2
Filing date	Jul 19, 2012
Priority date	Sep 1, 2011
Publication date	Mar 21, 2017
Grant date	Mar 21, 2017

Abstract

A plunger is moved downwardly in predetermined distance while the tip of the sample probe is immersed in a sample to suck the sample into the probe. A pressure sensor detects the pressure fluctuation during the suction operation, an AD converter converting the signals into digital signals to send the signals for a signal processing unit. The signal processing unit extracts feature variables data of a suction waveform to calculate the Statistical distance from normal group data. The Statistical distance an a threshold value are compared with each other, it is judged that there is an abnormality in the suction operation when the Statistical distance is more than or equal to the threshold value. When the Statistical distance is smaller than the threshold value, an operation is proceeded to a discharge operation.

First claim

The invention claimed is:

1. An automatic analyzer comprising:
a dispensing mechanism including a dispensing probe for dispensing a sample or a reagent into a reaction container;
a quantitative pump for sucking and discharging the sample or the reagent quantitatively through the dispensing probe, the quantitative pump being driven during a plurality of different periods of time, each beginning at a drive start time and ending at a drive end time, and each time period corresponding to an amount of a sample or a reagent being sucked or discharged;
an analysis part for analyzing a sample in the reaction container;
a pressure sensor for detecting a pressure in the probe; and
a signal processing unit, having a memory, and programmed to:
extract feature variables from pressure data detected by the pressure sensor at a dispensing operation of the dispensing probe based on a first reference time which is the drive start time for driving the quantitative pump at the dispensing operation of the dispensing probe;
extract feature variables from pressure data detected by the pressure sensor at the dispensing operation of the dispensing probe based on a second reference time which is the drive end time for driving the quantitative pump at the dispensing operation of the dispensing probe;
calculate a statistical distance between predetermined common reference pressure fluctuation data, that is stored in the memory, and the feature variables regardless of the amount of sample or reagent; and
judge whether or not the dispensing operation of the dispensing probe is correctly executed based on whether or not the calculated statistical distance is lower than a constant threshold value,
wherein the reference pressure fluctuation data stored in the memory of the signal processing unit are plural kinds of reference pressure fluctuation data whose dispensing conditions, including an amount of sample or reagent, are different from one another.

2. The automatic analyzer according to claim 1 , wherein
the statistical distance calculated by the signal processing unit is one of a Mahalanobis distance, a Euclidean distance, a Chebychev distance, a Multi variate normal density, and a Minkowski distance.

3. The automatic analyzer according to claim 1 , wherein
the signal processing unit judges whether or not a dispensing operation is correctly executed by using both of pressure data of the dispensing probe sucking operation and discharging operation of sample or reagent.

4. The automatic analyzer according to claim 1 , wherein
the reference pressure fluctuation data is data of a pressure waveform obtained by dispensing a liquid whose viscosity has a viscosity range substantially equal to a viscosity range of a normal sample or a normal reagent.

5. The automatic analyzer according to claim 1 , wherein
the signal processing unit uses abnormal group pressure data caused by a specific reason as the reference pressure fluctuation data, discriminating a kind of an abnormality, when the signal processing unit judges that the dispensing probe could not execute a dispensing operation correctly.

6. A method for judging whether a dispensing operation of an automatic analyzer is normal or abnormal, the automatic analyzer having a dispensing mechanism including a dispensing probe for dispensing a sample or a reagent into a reaction container and a quantitative pump for sucking and discharging the sample or the reagent quantitatively through the dispensing probe, the quantitative pump being driven during a plurality of different periods of time, each beginning at a drive start time and ending at a drive end time, and each time period corresponding to an amount of a sample or a reagent being sucked or discharged, an analysis part for analyzing a sample in the reaction container, and a pressure sensor for detecting a pressure in the probe, the method comprising the steps of:
extracting feature variables from pressure data detected by the pressure sensor at a dispensing operation of the dispensing probe based on a first reference time which is the drive start time for driving the quantitative pump at the dispensing operation of the dispensing probe;
extracting feature variables from pressure data detected by the pressure sensor at the dispensing operation of the dispensing probe based on a second reference time which is the drive end time for driving the quantitative pump at the dispensing operation of the dispensing probe;
calculating a statistical distance between predetermined common reference pressure fluctuation data and the feature variables regardless of the amount of sample or reagent; and
judging whether or not the dispensing operation of the dispensing probe is correctly executed based on whether or not the calculated statistical distance is lower than a constant threshold value,
wherein the reference pressure fluctuation data of the signal processing unit are plural kinds of reference pressure fluctuation data whose dispensing conditions, including an amount of sample or reagent, are different from one another.

7. The method for judging normal or abnormal of a dispensing operation of an automatic analyzer according to claim 6 , wherein
the statistical distance to be calculated is one of a Mahalanobis distance, a Euclidean distance, a Chebychev distance, a Multi variate normal density, and a Minkowski distance.

8. The method for judging normal or abnormal of a dispensing operation of an automatic analyzer according to claim 6 , wherein
whether or not a dispensing operation is correctly executed is judged by using both of pressure data of the dispensing probe sucking operation and discharging operation of sample or reagent.

9. The method for judging normal or abnormal of a dispensing operation of an automatic analyzer according to claim 6 , wherein
the reference pressure fluctuation data is data of a pressure waveform obtained by dispensing a liquid whose viscosity has a viscosity range substantially equal to a viscosity range of a normal sample or a normal reagent.

10. The method for judging normal or abnormal of a dispensing operation of an automatic analyzer according to claim 6 , wherein
abnormal group pressure data caused by specific reason are used as the reference pressure fluctuation data, and a kind of an abnormality is discriminated when the signal processing unit judges that the dispensing probe could not execute a dispensing operation correctly.

11. The automatic analyzer according to claim 1 , wherein
the feature variables include:
pressure values at constant timings based on the first reference time, a time elapsed from the first reference time to a first occurrence of a maximum or a minimum pressure fluctuation, a pressure value of the maximum or minimum pressure fluctuation from the first reference time, pressure values at constant timing based on the second reference time, a time elapsed from the second reference time to a first occurrence of a maximum or a minimum pressure fluctuation, and a pressure value of the maximum or minimum pressure fluctuation from the second reference time.

12. The method according to claim 6 , wherein
the feature variables include:
pressure values at constant timings based on the first reference time, a time elapsed from the first reference time to a first occurrence of a maximum or a minimum pressure fluctuation, a pressure value of the maximum or minimum pressure fluctuation from the first reference time, pressure values at constant timing based on the second reference time, a time elapsed from the second reference time to a first occurrence of a maximum or a minimum pressure fluctuation, and a pressure value of the maximum or minimum pre

Assignees

• Yamazaki Isao
• Nishida Masaharu
• Kamihara Kumiko
• TAMEZANE Hideto
• Hitachi High Tech Corp

Inventors

• Yamazaki Isao
• Nishida Masaharu
• Kamihara Kumiko
• TAMEZANE Hideto

Classifications

• Y10T436/119163

  with aspirator of claimed structure · CPC title

• G01N35/1002 Primary

  Reagent dispensers · CPC title

• G01N35/1016 Primary

  Control of the volume dispensed or introduced · CPC title

• G01N2035/1062

  for testing the liquid while it is in the transfer device · CPC title

• G01N2035/1018

  Detecting inhomogeneities, e.g. foam, bubbles, clots · CPC title