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Plasma H2S levels as biomarkers for vascular disease
US9599602B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9599602-B2 |
| Application number | US-201314435231-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 22, 2013 |
| Priority date | Oct 24, 2012 |
| Publication date | Mar 21, 2017 |
| Grant date | Mar 21, 2017 |
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Abstract
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Hydrogen sulfide (H 2 S) levels in plasma are useful in diagnosing cardiovascular disease. The ratio of H 2 S to NO in plasma is useful in diagnosing peripheral artery disease.
First claim
Opening claim text (preview).
What is claimed: 1. A method for treating peripheral artery disease in a vertebrate patient, said method comprising the steps of: (a) assaying plasma free H 2 S concentration and plasma NO concentration in a blood sample from a patient, wherein the plasma free H 2 S concentration is assessed using monobromobimane; and identifying the patient as having peripheral artery disease if the ratio of the concentration of plasma free H 2 S in the patient to the concentration of plasma NO in the patient is at least 129% higher than a mean ratio in a control population having no peripheral artery disease; and (b) administering a therapeutic for peripheral artery disease to the patient if the patient is thus identified as having peripheral artery disease. 2. The method of claim 1 wherein the therapeutic for peripheral artery disease is one of a statin, cilostazol, a suitable NO-based drug or NO prodrug, cardiac catheterization, vascular stent placement, vascular angioplasty, vascular bypass surgery, and supervised exercise therapy. 3. The method of claim 1 , further comprising the steps of forming a sulfide-dibimane derivative and measuring an amount of sulfide-dibimane to determine the free H 2 S concentration in the plasma. 4. A method for treating peripheral artery disease in a vertebrate patient, said method comprising the steps of: (a) assaying plasma free H 2 S concentration and plasma NO concentration in a blood sample from the patient, wherein the plasma free H 2 S concentration is assessed using monobromobimane; and identifying the patient as having peripheral artery disease if the ratio of a molar ratio of the concentration of plasma free H 2 S in the patient to the concentration of plasma NO in the patient is above 6.5; and (b) administering a therapeutic for peripheral artery disease to the patient if the patient is thus identified as having peripheral artery disease. 5. The method of claim 4 , wherein the ratio of the molar ratio of the concentration of plasma free H 2 S in the patient to the concentration of plasma NO in the patient is above 8. 6. The method of claim 4 , wherein the ratio of the molar ratio of the concentration of plasma free H 2 S in the patient to the concentration of plasma NO in the patient is above 10.
Assignees
Inventors
Classifications
- G01N33/4925Primary
measuring blood gas content, e.g. O2, CO2 , HCO3 · CPC title
Cardiovascular disorders · CPC title
Coronary artery diseases, e.g. angina pectoris, myocardial infarction · CPC title
involving inorganic compounds or pH · CPC title
related to diseases not provided for elsewhere · CPC title
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- What does patent US9599602B2 cover?
- Hydrogen sulfide (H 2 S) levels in plasma are useful in diagnosing cardiovascular disease. The ratio of H 2 S to NO in plasma is useful in diagnosing peripheral artery disease.
- Who is the assignee on this patent?
- Kevil Christopher G, Peter Elvis A, Shen Xinggui, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/4925. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 21 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).