Particles coated with zwitterionic polymers comprising sulfobetaine or carboxybetaine

Patent metadata

Field	Value
Publication number	US-9598544-B2
Application number	US-201414184540-A
Country	US
Kind code	B2
Filing date	Feb 19, 2014
Priority date	Aug 25, 2005
Publication date	Mar 21, 2017
Grant date	Mar 21, 2017

Abstract

Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.

First claim

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A surface having a layer of sulfobetaine polymers coupled thereto, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm 2 in a fibrinogen binding assay when the surface is incubated at 37° C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).

2. The surface of claim 1 , wherein the sulfobetaine polymers are prepared from one or more monomers selected from the group consisting of a sulfobetaine acrylate, a sulfobetaine acrylamide, a sulfobetaine methacrylate, and mixtures thereof.

3. The surface of claim 1 , wherein the layer of sulfobetaine polymers comprises an interpenetrating sulfobetaine polymer network.

4. The surface of claim 3 , wherein the interpenetrating sulfobetaine polymer network further comprises one or more polymers selected from the group consisting of a polyurethane, a silicone, a polyester, a polyethylene, and a polyamide.

5. The surface of claim 1 , wherein the layer of sulfobetaine polymers comprises a sulfobetaine copolymer.

6. The surface of claim 1 , wherein the layer comprises sulfobetaine polymers covalently attached to a substrate surface.

7. The surface of claim 1 on all or part of a particle.

8. The surface of claim 1 , wherein the fibrinogen adsorption is less than 10 ng/cm 2 .

9. The surface of claim 1 , wherein the fibrinogen adsorption is less than 5 ng/cm 2 .

10. The surface of claim 1 , wherein the fibrinogen adsorption is less than 0.3 ng/cm 2 .

11. The surface of claim 1 , wherein the sulfobetaine polymers are prepared from one or more monomers selected from the group consisting of a sulfobetaine vinyl compound, a sulfobetaine epoxide, and mixtures thereof.

12. A substrate comprising a surface having a layer of sulfobetaine polymers grafted from the surface, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm 2 in a fibrinogen binding assay when the surface is incubated at 37° C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).

13. The substrate of claim 12 , wherein the sulfobetaine polymers are prepared from one or more monomers selected from the group consisting of a sulfobetaine acrylate, a sulfobetaine acrylamide, a sulfobetaine methacrylate, and mixtures thereof.

14. The substrate of claim 12 , wherein the layer of sulfobetaine polymers comprises a sulfobetaine copolymer.

15. The substrate of claim 12 , wherein the fibrinogen adsorption is less than 10 ng/cm 2 .

16. The substrate of claim 12 , wherein the fibrinogen adsorption is less than 5 ng/cm 2 .

17. The substrate of claim 12 , wherein the fibrinogen adsorption is less than 0.3 ng/cm 2 .

18. The substrate of claim 12 on or forming all or part of a particle.

19. The substrate of claim 12 , wherein the sulfobetaine polymers are prepared from one or more monomers selected from the group consisting of a sulfobetaine vinyl compound, a sulfobetaine epoxide, and mixtures thereof.

Assignees

• Univ Washington
• Univ Washington Through Its Center For Commercialization

Inventors

• Jiang Shaoyi
• Chen Shengfu
• Chang Yung
• Zhang Zheng

Classifications

• C08J3/075 Primary

  Macromolecular gels · CPC title

• C07C317/28

  with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton · CPC title

• C08K9/08

  Ingredients agglomerated by treatment with a binding agent · CPC title

• C08F2438/01

  Atom Transfer Radical Polymerization [ATRP] or reverse ATRP · CPC title

• C07C317/50

  at least one of the nitrogen atoms being part of any of the groups [IMAGE cpc-sch-C07C-0976.gif], X being a hetero atom, Y being any atom · CPC title