Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases

Patent metadata

Field	Value
Publication number	US-9598338-B2
Application number	US-201314390960-A
Country	US
Kind code	B2
Filing date	Apr 8, 2013
Priority date	Apr 6, 2012
Publication date	Mar 21, 2017
Grant date	Mar 21, 2017

Abstract

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.

First claim

We claim:

1. A method of reducing intracellular tau levels, wherein said method comprises administering, to cells comprising protein tau, an effective amount of a compound of formula A, formula C to formula F, or formula J to formula L:

wherein each of R 1 -R 4 of formula A, formula C, formula D, formula F, formula J, formula K, and formula L is, independently, —H or any group that forms an ester or ether bond;
wherein each of R 1 -R 8 of formula E is, independently, H or any group that forms an ester or ether bond;
whereby intracellular tau level is reduced.

2. The method according to claim 1 , wherein the compound has a chemical structure of formula A.

3. The method according to claim 1 , wherein the compound has a chemical structure of formula C.

4. The method according to claim 1 , wherein the compound is Compound 22, or Compound 24:

5. The method according to claim 1 , wherein the cells are in a subject in need of treatment for a neurodegenerative disease.

6. The method of claim 5 , wherein the neurodegenerative disease is a tauopathy.

7. The method of claim 6 , wherein the subject is a human.

8. The method of claim 7 , wherein the neurodegenerative disease is selected from Alzheimer's disease, Parkinson's disease, frontotemporal dementia, frontotemporal dementia with Parkinsonism, frontotemporal lobe dementia, pallidopontonigral degeneration, progressive supranuclear palsy, multiple system tauopathy, multiple system tauopathy with presenile dementia, Wilhelmsen-Lynch disease, Pick's disease, and Pick's disease-like dementia.

9. The method of claim 8 , wherein the neurodegenerative disease is Alzheimer's disease.

Assignees

• Dickey Chad
• Jinwal Umesh
• Calcul Laurent
• Baker Bill J
• Lebar Matthew
• Univ South Florida
• The Dept Of Veterans Affairs

Inventors

• Dickey Chad
• Jinwal Umesh
• Calcul Laurent
• Baker Bill J
• Lebar Matthew

Classifications

• C07C43/21

  containing rings other than six-membered aromatic rings · CPC title

• C07C2603/40

  containing four condensed rings · CPC title

• C07C43/215

  having unsaturation outside the six-membered aromatic rings · CPC title

• C07C47/277

  containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] groups · CPC title

• C07B2200/07

  Optical isomers · CPC title