Continuous coating of pellets

Patent metadata

Field	Value
Publication number	US-9597294-B2
Application number	US-201414514464-A
Country	US
Kind code	B2
Filing date	Oct 15, 2014
Priority date	Feb 21, 2007
Publication date	Mar 21, 2017
Grant date	Mar 21, 2017

Abstract

A continuous dosage form coating apparatus uses vibrational impulses to maintain a dosage forms in a fluid state to expose them to a coating material atomized by spraying.

First claim

The invention claimed is:

1. A process for continuously coating pellets comprising:
feeding pellets continuously into a linearly elongated trough, said trough having a concave trough bottom wall extending laterally from a first longitudinal side edge to an opposite second longitudinal side edge, said pellets being introduced into the trough at a first location along the length of the trough, and thereby maintaining a bed of pellets continuously moving longitudinally in the trough;
directing a spray of liquefied pellet coating material toward the bed of pellets in the trough at least at one intermediate location along the length of the trough;
causing reciprocating rotational vibration of the trough about a pivot axis parallel to the direction of elongation of the trough but laterally offset from a longitudinal centerline of the trough, said centerline being positioned above a location on said concave trough bottom midway between said first and second longitudinal side edges by applying impulse components to the trough as moments about said pivot axis, said reciprocating rotational vibration having sufficient intensity substantially to fluidize the bed of pellets disposed in said trough, thereby causing the pellets in said bed to circulate, substantially continuously and in the same direction, in a loop-shaped path transverse to the direction of elongation of the trough, as they move longitudinally in the trough, so that substantially all of the pellets are exposed to the spray at times during their travel along the trough; and
collecting coated pellets discharged over a weir in the trough at a discharge location longitudinally spaced from the first location, the at least one intermediate location at which the spray is directed toward the bed of pellets being between the first location and the discharge location.

2. The process of claim 1 , in which said pivot axis is a stationary pivot axis.

3. The process of claim 1 , in which the liquefied pellet coating material is sprayed toward the bed of pellets in the trough by a spray nozzle located at a sufficient distance from the pellets that the coating material reaches the pellets in a partially dried condition such that solvent in the coating material does not damage the pellets.

4. The process of claim 1 , in which the bed of pellets is moved along the trough over at least one additional weir in the trough, the additional weir being spaced longitudinally from the weir at the discharge location.

5. The process of claim 1 , in which the bed of pellets is moved along the trough over a series of longitudinally spaced weirs in the trough in addition to the weir at the discharge location.

6. The process of claim 1 , in which air is caused to flow through the bed of pellets while the spray of liquefied pellet coating material is directed toward the bed of pellets.

7. The process of claim 1 , in which the bed of pellets is moved along the trough over at least one hollow weir in the trough, spaced longitudinally from the weir at the discharge location, and in which air is caused to flow through the bed of pellets and outwardly from the trough through an array of openings in the hollow weir while the spray of liquefied coating material is directed toward the bed of pellets.

8. The process of claim 1 , in which a condition of the coating process is monitored, and, in response to the monitored condition, at least one operating parameter is adjusted automatically in response to the monitored condition, the operating parameter being from the group consisting of the rate at which the pellets to be coated are fed to the trough, air temperature, air flow, vibration amplitude, vibration intensity, vibration frequency, vibration direction, liquefied coating material spray rate and spray pressure.

9. The process of claim 8 , in which air is caused to flow through the bed of pellets while the spray of liquefied pellet coating material is directed toward the bed of pellets.

10. The process of claim 1 , in which the outlet end of the elongated trough is lower than the inlet end, whereby the trough is tilted downward in the direction of travel of pellets in the trough, and in which, in the feeding of pellets continuously into the trough at said first location, pellets are fed at a rate that maintains the surface of the bed of pellets substantially parallel to the direction of elongation of the trough.

11. The process of claim 1 , in which the vibration of the trough is carried out at a frequency in the range from 500 to 3500 Hz.

12. The process of claim 1 , in which said pivot axis extends alongside the trough.

13. The process of claim 1 , in which said pivot axis extends alongside the trough on one side of the trough, and said impulse components are applied to the trough through an arm structure extending from the opposite side of trough and away from the trough.

Assignees

• Glaxosmithkline Llc

Inventors

• Fiesser Frederick Henry

Classifications

• A61K9/5089 Primary

  Processes · CPC title

• B05D2258/00

  Small objects (e.g. screws) · CPC title

• B05C5/022

  the outlet being fixed during operation · CPC title

• B01J2/18

  using a vibrating apparatus · CPC title

• A61J3/005

  Coating of tablets or the like (coating of sweetmeats or confectionery A23G3/20; coating of granules in general B01J2/006) · CPC title