Prosthetic renal valve

Patent metadata

Field	Value
Publication number	US-9597205-B2
Application number	US-201314405144-A
Country	US
Kind code	B2
Filing date	Jun 6, 2013
Priority date	Jun 6, 2012
Publication date	Mar 21, 2017
Grant date	Mar 21, 2017

Abstract

Apparatus and methods are described including a valve ( 34 ) that includes valve leaflets ( 33 ) and a non-branched valve frame ( 31 ) configured to support the valve leaflets, the frame defining a single longitudinal axis thereof, the longitudinal axis being a generally straight line along a full length of the frame. The valve ( 34 ) is placed at least partially within a renal vein of a subject. The valve defines an open state thereof in which the valve leaflets ( 33 ) allow generally unimpeded antegrade blood flow therethrough, and a closed state thereof in which the valve leaflets ( 33 ), in a passive manner, reduce venous pressure within the renal vein relative to central venous pressure of the subject. Other applications are also described.

First claim

The invention claimed is:

1. A method comprising:
identifying a subject as suffering from a condition that causes the subject to have elevated renal venous pressure even in an absence of a condition that causes renal venous pressure of the subject to be elevated due to pressure being exerted on the subject's renal vein through walls of the subject's renal vein from a location outside the renal vein; and
in response thereto, reducing blood pressure within a renal vein of the subject relative to the subject's central venous pressure, by placing a device at least partially within the subject's renal vein, the device being configured, in a passive manner, to reduce venous pressure within the subject's renal vein relative to central venous pressure of the subject.

2. A method comprising:
identifying a subject as suffering from a condition that causes the subject to have elevated central venous pressure; and
in response thereto, reducing blood pressure within renal veins of the subject relative to the subject's central venous pressure, by placing a first device at least partially in a left renal vein of the subject and placing a second device at least partially in a right renal vein of the subject, the devices being configured, in a passive manner, to reduce venous pressure within the subject's renal veins relative to central venous pressure of the subject.

3. A method comprising:
identifying a subject as suffering from a condition that causes the subject to have elevated central venous pressure, the condition being selected from the group consisting of: cardiac dysfunction, congestive heart failure, and kidney dysfunction; and
in response thereto, reducing blood pressure within a renal vein of the subject relative to the subject's central venous pressure, by placing a device at least partially within the subject's renal vein, the device being configured, in a passive manner, to reduce venous pressure within the subject's renal vein relative to central venous pressure of the subject.

4. The method according to claim 3 , wherein reducing pressure within the renal vein comprises reducing pressure within the renal vein by placing the device at least partially within the renal vein in an absence of any device being placed at a location that is within an abdomen of the subject and outside a venous system of the subject.

5. The method according to claim 3 , wherein identifying the subject as suffering from the condition that causes the subject to have elevated central venous pressure comprises identifying the subject as suffering from elevated renal venous pressure.

6. The method according to claim 3 , wherein identifying the subject as suffering from the condition that causes the subject to have elevated central venous pressure comprises identifying the subject as suffering from elevated central venous pressure even in an absence of the subject suffering from tricuspid valve regurgitation.

7. The method according to claim 3 , wherein reducing the blood pressure within the renal vein comprises reducing the blood pressure within the subject's renal vein relative to central venous pressure of the subject, even during lower body exercise that is performed by the subject.

8. The method according to claim 3 , wherein identifying the subject as suffering from the condition comprises identifying the subject as suffering from a condition selected from the group consisting of: cardiac dysfunction, and congestive heart failure.

9. A method comprising:
identifying a subject as suffering from a condition that causes the subject to have elevated central venous pressure; and
in response thereto, reducing blood pressure within a renal vein of the subject relative to the subject's central venous pressure, by placing a valve at least partially within the subject's renal vein, the valve being configured, in a passive manner, to reduce venous pressure within the subject's renal vein relative to central venous pressure of the subject.

10. The method according to claim 9 , wherein placing the valve at least partially within the subject's renal vein, comprises placing at least partially within the subject's renal vein a valve that includes valve leaflets, such that in an open state of the valve, the valve leaflets allow generally unimpeded antegrade blood flow therethrough.

11. The method according to claim 9 , wherein placing the valve at least partially within the subject's renal vein comprises reducing compression of the renal vein resulting from intra-abdominal pressure that is exerted on the renal vein, relative to a level of compression of the renal vein resulting from intra-abdominal pressure that is exerted on the renal vein in an absence of the valve.

12. The method according to claim 9 , wherein placing the valve at least partially within the renal vein comprises forming a bulged portion within the subject's renal vein by placing at least partially within the renal vein a valve that includes:
a narrow portion thereof to which the valve leaflets are coupled, and
a bulging portion that is bulged with respect to the narrow portion, and that is configured to cause the renal vein to form a bulged portion in a vicinity of the valve leaflets.

13. The method according to claim 9 , wherein placing the valve at least partially within the renal vein comprises forming a bulged portion within the subject's renal vein by placing at least partially within the renal vein a valve that includes:
valve leaflets; and
a frame configured to support the valve leaflets, the frame defining:
a cylindrical portion thereof that defines an outer surface thereof, and
at least one protruding portion thereof, the protruding portion being shaped such as to form the bulged portion by diverging radially from the outer surface of the cylindrical portion, such that a separation between the protruding portion and the outer surface of the cylindrical portion is greater at a downstream end of the protruding portion than at an upstream end of the protruding portion.

14. The method according to claim 13 , wherein placing the valve at least partially within the renal vein comprises placing at least partially within the renal vein a valve, the protruding portion of the valve being shaped to be disposed outside of radial projections of downstream edges of the valve leaflets, such that even when the valve leaflets are in open states thereof, the valve leaflets do not contact the protruding portion.

15. The method according to claim 13 , wherein placing the valve at least partially within the renal vein comprises placing the valve at least partially within the renal vein, the valve leaflets of the valve being coupled to the frame downstream of the protruding portion, such that an upstream end of each of the valve leaflets is longitudinally spaced from a downstream end of the protruding portion.

16. The method according to claim 13 , wherein placing the valve at least partially within the renal vein comprises placing at least partially within the renal vein a valve, the protruding portion of the valve diverging from the outer surface of the cylindrical portion of the valve at an angle of greater than 40 degrees with respect to the outer surface of a downstream portion of the cylindrical portion.

17. The method according to claim 13 , wherein placing the valve at least partially within the renal vein comprises placing the valve at least partially within the renal vein such that the valve leaflets are disposed within the bulged portion.

18. The method according to claim 17 , wherein placing the valve at least partially within

Assignees

• Magenta Medical Ltd

Inventors

• Tuval Yosi

Classifications

• A61F2230/0054

  V-shaped · CPC title

• A61F2250/006

  modular · CPC title

• A61F2/966

  with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod · CPC title

• A61F2230/005

  Rosette-shaped, e.g. star-shaped · CPC title

• A61F2230/0067

  conical · CPC title