C-Met Modulators and Methods of Use
US-2015376133-A1 · Dec 31, 2015 · US
US9593083B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9593083-B2 |
| Application number | US-201314418449-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 14, 2013 |
| Priority date | Sep 4, 2012 |
| Publication date | Mar 14, 2017 |
| Grant date | Mar 14, 2017 |
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The present invention provides process for preparation of Crystalline Erlotinib HCl (I) Form-SE characterized by X-ray powder diffraction pattern comprising at least 5 characteristic 2θ° peaks selected from the XRPD peak set of 5.60, 10.00, 11.40, 13.00, 13.50, 15.20, 18.40, 20.65, 21.86, 23.5, 31.80, 32.13, 32.80, 34.40±0.20 2θ°, DSC isotherm comprising the endothermic peaks ranging between 213 to 217° C. (Peak −1) and 225 to 235° C. (Peak −2) and IR absorption characteristic peaks at approximately 3278 cm −1 , 1948 cm −1 , 1871 cm −1 , 1632 cm −1 , 1164 cm −1 , 1024 cm −1 , 940 cm −1 and 742 cm −1 useful as active pharmaceutical ingredient in pharmaceutical compositions for the treatment cancer.
Opening claim text (preview).
We claim: 1. Erlotinib hydrochloride (I) crystalline Form-SE characterized by X-ray powder diffraction pattern according to FIG.- 1 .
Nitrogen atoms · CPC title
Crystalline forms, e.g. polymorphs · CPC title
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