Inducible tissue constructs and uses thereof
US-2024287463-A1 · Aug 29, 2024 · US
Scaffold-free three dimensional nerve fibroblast constructs
US9592255B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9592255-B2 |
| Application number | US-201113805486-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 1, 2011 |
| Priority date | Jul 1, 2010 |
| Publication date | Mar 14, 2017 |
| Grant date | Mar 14, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.
First claim
Opening claim text (preview).
What is claimed is: 1. A self-organizing, scaffold-free, three-dimensional nerve-fibroblast construct comprising an inner core of nerve cells surrounded by an external sheath of fibroblasts for use in repairing a nerve transection or replacing damaged tissue, wherein neural markers are absent from the fibroblast sheath. 2. The construct of claim 1 , wherein the fibroblasts or nerve cells are derived from adipose-derived stem cells. 3. The system of claim 1 , wherein the fibroblasts and nerve cells are derived from adipose-derived stem cells. 4. A method of repairing a nerve transection in a subject comprising inserting the three-dimensional nerve fibroblast construct of claim 1 in a subject in need to repair the nerve transection. 5. A method of replacing damaged nerve tissue in a subject comprising inserting the three-dimensional nerve fibroblast construct of claim 1 in a subject in need to replace the damaged nerve tissue.
Assignees
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Classifications
as distinct cell layers · CPC title
characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells · CPC title
Fibronectin; Laminin · CPC title
Adult fibroblasts · CPC title
Mineral substrates · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9592255B2 cover?
- The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.
- Who is the assignee on this patent?
- Larkin Lisa M, Arruda Ellen M, Baltich Jennifer, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61K35/33. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 14 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).