Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating HCV infections

Patent metadata

Field	Value
Publication number	US-9592222-B2
Application number	US-201615271066-A
Country	US
Kind code	B2
Filing date	Sep 20, 2016
Priority date	May 27, 2011
Publication date	Mar 14, 2017
Grant date	Mar 14, 2017

Abstract

The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I

D-M-D  (Formula I)

useful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A is

Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.

First claim

What is claimed is:

1. A pharmaceutical composition comprising from about 10 mg to about 1,000 mg of a compound of the structure:

or its pharmaceutically acceptable salt, in a pharmaceutically acceptable carrier.

2. The pharmaceutical composition of claim 1 , which is suitable for oral delivery.

3. The pharmaceutical composition of claim 2 , which is a tablet.

4. The pharmaceutical composition of claim 2 , which is a capsule.

5. The pharmaceutical composition of claim 1 , which is suitable for parenteral delivery.

6. The pharmaceutical composition of claim 1 , which is suitable for topical delivery.

Assignees

• Achillion Pharmaceuticals Inc

Inventors

• Wiles Jason Allan
• Wang Qiuping
• Hashimoto Akihiro
• Pais Godwin
• Wang Xiangzhu
• Gadhachanda Venkat
• Phadke Avinash
• Deshpande Milind
• Chen Dawei

Classifications

• C07F17/02

  of metals of Groups 8, 9 or 10 of the Periodic Table · CPC title

• C07D471/08

  Bridged systems · CPC title

• C07F15/02

  Iron compounds · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title

• C07D519/00

  Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 · CPC title