Cellulose powder

Patent metadata

Field	Value
Publication number	US-9592199-B2
Application number	US-201314403297-A
Country	US
Kind code	B2
Filing date	May 30, 2013
Priority date	May 31, 2012
Publication date	Mar 14, 2017
Grant date	Mar 14, 2017

Abstract

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 μm, but less than 250 μm; an apparent specific volume of 2 to less than 15 cm 3 /g; and a particle size distribution sharpness of 1.5 to 2.9.

First claim

The invention claimed is:

1. A cellulose powder having:
an average degree of polymerization of 100 to 350,
a weight average particle size of more than 30 μm and 250 μm or less,
an apparent specific volume of 2 to less than 15 cm 3 /g,
a sharpness of particle size distribution of 1.5 to 2.9, and
an angle of repose of 36° or more and less than 44°.

2. The cellulose powder according to claim 1 , wherein the apparent specific volume is 2 to 6 cm 3 /g.

3. The cellulose powder according to claim 1 , wherein the apparent specific volume is 2 cm 3 /g or more and less than 4 cm 3 /g.

4. The cellulose powder according to claim 1 , wherein an intraparticle pore volume is 0.1 cm 3 /g or more and less than 0.265 cm 3 /g.

5. The cellulose powder according to claim 1 , wherein an amount of organic carbon derived from residual impurities is more than 0.07 and 0.25% or less, the amount of organic carbon derived from residual impurities being defined by an expression (amount of total organic carbon (%) during extraction with aqueous solution of 1% NaOH)−(amount of total organic carbon (%) during extraction with pure water).

6. The cellulose powder according to claim 1 , wherein the sharpness of particle size distribution is 1.5 to less than or equal to 2.2.

7. The cellulose powder according to claim 1 , wherein a moisture retention rate is 180 to 250%.

8. A molded article, comprising a cellulose powder according to any one of claims 1 to 7 .

9. The molded article according to claim 8 , wherein the molded article contains one or more active ingredients.

10. A method of preparing a cellulose powder, comprising:
hydrolyzing a natural cellulose substance at a hydrochloric acid concentration of 0.05 to 0.3% at a hydrolysis temperature of 100 to 150° C. for a hydrolysis time of 40 to 110 minutes to control a volume average particle size of particles in a cellulose dispersion liquid after the hydrolysis to be 70 to 150 μm, and then
spray drying the resulting dispersion liquid to prepare a cellulose powder having:
an average degree of polymerization of 100 to 350,
a weight average particle size of the cellulose powder of more than 30 μm and 250 μm or less,
an apparent specific volume of 2 to 15 cm 3 /g,
a sharpness of particle size distribution of 1.5 to 2.9, and
an angle of repose of 36° or more and less than 44°.

11. A molded article comprising:
one or more active ingredients, one or more additives selected from saccharides, sugar alcohols, starches, and disintegrating agents, and a cellulose powder,
wherein the molded article has a hardness of 50 to 200 N, a tensile strength of 0.1 to 12 MPa, a friability of 0 to 0.5%, a swelling rate of a diameter of the molded article in acetone of 0 to 3.3% or less, and a disintegration time of 20 minutes or less, and
wherein the cellulose powder has:
an average degree of polymerization of 100 to 350,
a weight average particle size of more than 30 μm and 250 μm or less,
an apparent specific volume of 2 to less than 15 cm 3 /g,
a sharpness of particle size distribution of 1.5 to 2.9, and
an angle of repose of 36° or more and less than 44°.

12. The molded article according to claim 11 , comprising 5 to 90% by weight of the cellulose powder.

13. The molded article according to claim 11 or 12 , wherein an amount of total organic carbon derived from residual impurities in molded article residues obtained through washing of the molded article with acetone, ethanol, pure water, and ethanol sequentially and extraction is more than 0.07 and 0.25% or less.

14. The molded article according to claim 11 or 12 , wherein an amount of total organic carbon derived from residual impurities in the cellulose powder obtained through washing of the molded article with acetone, ethanol, pure water, and ethanol sequentially and extraction is more than 0.07 and 0.25% or less.

Assignees

• Asahi Kasei Chemicals Corp

Inventors

• Obae Kazuhiro
• Kakizawa Masayuki
• Yamashita Mitsuo
• Matsui Shinji

Classifications

• C08L1/02 Primary

  Cellulose; Modified cellulose · CPC title

• A61K9/2054

  Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title

• C08J2301/04

  Oxycellulose; Hydrocellulose · CPC title

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title