Multilayered tissue phantoms, fabrication methods, and use

Patent metadata

Field	Value
Publication number	US-9588042-B2
Application number	US-201414536157-A
Country	US
Kind code	B2
Filing date	Nov 7, 2014
Priority date	Jun 2, 2009
Publication date	Mar 7, 2017
Grant date	Mar 7, 2017

Abstract

A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighboring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging.

First claim

What is claimed is:

1. A phantom comprising a chamber covered by a lumen, the lumen including at least 2 polymer-based layers having different compositions and exhibiting different scattering and attenuation values within optical and infrared regions of the electromagnetic spectrum, wherein one of the at least 2 polymer-based layers has a thickness less than 25 μm.

2. The phantom according to claim 1 wherein a solid object is embedded in the lumen.

3. The phantom according to claim 1 wherein an uncertainty of the thickness of the at least 2 polymer-based layers is less than 10 μm.

4. The phantom according to claim 1 in a collection with a plurality of phantoms to serve as standard samples representative of a single tissue, each phantom respectively representing abnormal healthy tissue, normal healthy tissue or a pathological tissue state.

5. The phantom according to claim 3 in a collection with a plurality of phantoms to serve as standard samples representative of a single tissue, each phantom respectively representing abnormal healthy tissue, normal healthy tissue or a pathological tissue state.

6. A method of utilizing a phantom according to claim 1 comprising inserting the phantom into a first imaging system and imaging a portion of the phantom.

7. The method of claim 6 further comprising placing the phantom in contact with other tissue-like structures or liquids.

8. The method of claim 6 further comprising submitting the phantom to temperature variations or pressure variations that can be found normally or exceptionally in an animal.

9. The method of claim 6 further comprising testing a tool, process or implant on the phantom.

10. The method of claim 6 further comprising attaching a second phantom fabricated according to claim 1 to the phantom such that lumens are coupled.

11. The method of claim 6 further comprising comparing independently characterized parameters of the phantom to calibrate the first imaging system.

12. The method of claim 6 further comprising inserting the phantom into a second imaging system, imaging the phantom using the second imaging system, and comparing the image data from the first imaging system and the second imaging system to compare the first and second imaging systems.

13. The method of claim 6 further comprising operating the first imaging system in a training mode to provide the user with feedback on the operation.

14. A method of a phantom according to claim 4 comprising inserting the phantom into a first imaging system and imaging a portion of the phantom.

15. The method of claim 14 further comprising placing the phantom in contact with other tissue-like structures or liquids.

16. The method of claim 14 further comprising submitting the phantom to temperature variations or pressure variations that can be found normally or exceptionally in an animal.

17. The method of claim 14 further comprising testing a tool, process or implant on the phantom.

18. The method of claim 14 further comprising attaching a second phantom fabricated according to claim 1 to the phantom such that lumens are coupled.

19. The method of claim 14 further comprising comparing independently characterized parameters of the phantom to calibrate the first imaging system.

20. The method of claim 14 further comprising inserting the phantom into a second imaging system, imaging the phantom using the second imaging system, and comparing the image data from the first imaging system and the second imaging system to compare the first and second imaging systems.

Assignees

• Nat Res Council Canada

Inventors

• Bisaillon Charles-Etienne
• Lamouche Guy
• Dufour Marc L

Classifications

• G09B23/285 Primary

  for injections, endoscopy, bronchoscopy, sigmoidscopy, insertion of contraceptive devices or enemas · CPC title

• A61B2560/0228

  using calibration standards · CPC title

• A61B5/00

  Measuring for diagnostic purposes (radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00); Identification of persons · CPC title

• G01N2201/127

  Calibration; base line adjustment; drift compensation · CPC title

• G09B23/286

  for scanning or photography techniques, e.g. X-rays, ultrasonics · CPC title