Bi-Specific Fusion Proteins
US-2024101713-A1 · Mar 28, 2024 · US
IGF-I poly (ethylene glycol) conjugates
US9587006B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9587006-B2 |
| Application number | US-201113577284-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 4, 2011 |
| Priority date | Feb 11, 2010 |
| Publication date | Mar 7, 2017 |
| Grant date | Mar 7, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
Herein is reported a method for producing of a polypeptide conjugated to one poly (ethylene glycol) comprising a) providing a nucleic acid encoding an expression construct comprising in 5′ to 3′ direction a nucleic acid encoding a polypeptide, and a nucleic acid encoding a trypsin site of SEQ ID NO: 01, b) expressing the nucleic acid of a) in a cell and recovering the expression construct from the cell and/or the cultivation medium, c) providing a target peptide with an amino acid sequence of SEQ ID NO: 02 covalently conjugated to a poly (ethylene glycol) at the C-terminal lysine residue, d) incubating the expression construct and the target peptide with the trypsin mutant D189K, K60E, N143H, E151H, and e) recovering and thereby producing the polypeptide conjugated to one poly (ethylene glycol) from the incubation mixture.
First claim
Opening claim text (preview).
The invention claimed is: 1. A polypeptide consisting of the amino acid sequence of SEQ ID NO: 28 that is conjugated to poly (ethylene glycol) at the C-terminal lysine residue of the polypeptide. 2. A pharmaceutical composition comprising the polypeptide according to claim 1 . 3. A polypeptide consisting of the amino acid sequence of SEQ ID NO: 29 that is conjugated to poly (ethylene glycol) at the C-terminal lysine residue of the polypeptide.
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Classifications
Tetrapeptides · CPC title
produced by the hydrolysis of a peptide bond, e.g. hydrolysate products (preparing foodstuffs by protein hydrolysis A23J3/00) · CPC title
the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title
- C07K14/65Primary
Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 · CPC title
by covalent attachment of amino acids or peptide residues · CPC title
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- What does patent US9587006B2 cover?
- Herein is reported a method for producing of a polypeptide conjugated to one poly (ethylene glycol) comprising a) providing a nucleic acid encoding an expression construct comprising in 5′ to 3′ direction a nucleic acid encoding a polypeptide, and a nucleic acid encoding a trypsin site of SEQ ID NO: 01, b) expressing the nucleic acid of a) in a cell and recovering the expression construct from …
- Who is the assignee on this patent?
- Hesse Friederike, Hoess Eva, Mueller Stephanie, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/65. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 07 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).