Method for making ultra high molecular weight polyethylene

Patent metadata

Field	Value
Publication number	US-9586370-B2
Application number	US-201314052347-A
Country	US
Kind code	B2
Filing date	Oct 11, 2013
Priority date	Aug 15, 2013
Publication date	Mar 7, 2017
Grant date	Mar 7, 2017

Abstract

Heat treating UHMWPE by applying pressure with radial constraint at suitable times during a heating protocol reduces or eliminates cavitation, which is otherwise observed to occur when the UHMWPE is heated to a temperature above 300° C. Heat treated UHMWPE can undergo subsequent processing involving crosslinking, deformation, doping with antioxidant, and homogenizing or annealing. Heating during these steps can be carried out even above the onset melt temperature of the UHMWPE without loss of physical properties.

First claim

We claim:

1. A method comprising:
inserting a consolidated UHMWPE, in the form of a cylindrical bar of diameter from 2 inches to 4 inches, into a rigid sleeve, wherein the sleeve has a diameter greater than that of the UHMWPE bar, and wherein upon insertion, an inner wall of the sleeve contacts some but not all of the UHMWPE bar,
heating the UHMWPE in the sleeve to a temperature of 330° C. or higher, wherein the sleeve is dimensioned so that the heated UHMWPE thermally expands and contacts the entire inner wall of the sleeve during the heating so that the sleeve provides radial pressure to the heated UHMWPE and simultaneously leaves a longitudinal direction of the heated UHMWPE unconstrained,
cooling the heated UHMWPE, to provide a UHMWPE product, wherein during the cooling, the temperature of the UHMWPE is lowered to such an extent that the UHMWPE shrinks and loses contact with the inner wall of the sleeve, so that it can be removed from the sleeve, and
removing the UHMWPE from the sleeve,
wherein the UHMWPE product has less cavitation than a UHMWPE product made by a corresponding method free of the radial pressure.

2. The method according to claim 1 , wherein the sleeve is longer than the consolidated UHMWPE, and the consolidated UHMWPE fits wholly within the sleeve during the heating step.

3. The method according to claim 1 , wherein the heating is carried out in an inert atmosphere.

4. The method according to claim 1 , wherein the heating is carried out in a vacuum.

5. The method according to claim 1 , wherein the heating is carried out in nitrogen.

6. The method according to claim 1 , wherein the heating is carried out by bringing the oven to a temperature of 330° C. or higher and holding at 330° C. or higher for an hour or longer.

7. The method according to claim 6 , wherein the temperature is held at 330° C. or higher for about 5 hours or longer.

8. The method according to claim 1 , wherein the UHMWPE is heated in the sleeve to a temperature of 350° C. or higher.

9. The method according to claim 1 , wherein the consolidated UHMWPE has a diameter of about 3.75 inches and the sleeve has an inner diameter of about 3.875 inches.

10. The method according to claim 1 , wherein the UHMWPE product after cooling is characterized by diminished cavitation compared to that of a consolidated UHMWPE treated in the same way but without the sleeve.

11. A process for reducing or eliminating cavitation in a heat-treated UHMWPE product, the method comprising:
heating a consolidated UHMWPE at a temperature of 330° C. or higher while applying transverse pressure on the UHMWPE and simultaneously leaving an axial direction of the UHMWPE unconstrained, to provide the heat-treated UHMWPE product;
wherein the heat-treated UHMWPE product has less cavitation than a heat-treated UHMWPE product made by a corresponding method free of the transverse pressure.

12. The process according to claim 11 , wherein the consolidated UHMWPE is in the form of a cylindrical bar.

13. The process according to claim 11 , wherein pressure is applied by inserting the consolidated UHMWPE into a sleeve, and heating to 330° C. or higher with the UHMWPE in the sleeve.

14. The process according to claim 13 , wherein the consolidated UHMWPE is enclosed in a wrap material before insertion into the sleeve.

15. The process according to claim 13 , wherein the transverse pressure is applied by contact of the consolidated UHMWPE with the inner wall of the sleeve, as the consolidated UHMWPE thermally expands in the axial direction as a result of the heating.

16. The process according to claim 11 , wherein the pressure is applied only in the transverse direction.

17. The process according to claim 11 , wherein the heating is carried out in an inert atmosphere.

18. A method of producing wear resistant UHMWPE for use in bearing components of medical implants, comprising:
heat treating a consolidated UHMWPE by heating to 330° C. or higher while applying radial pressure and simultaneously leaving a longitudinal direction of the consolidated UHMWPE unconstrained, to form a UHMWPE product, wherein the UHMWPE product has less cavitation than a UHMWPE product made by a corresponding heat treatment free of the radial pressure;
crosslinking the UHMWPE product; and
subjecting the crosslinked UHMWPE to heating below its melting temperature or above its melting temperature, to provide the wear resistant UHMWPE.

19. The method of claim 18 , wherein the subjecting the crosslinked UHMWPE to heating comprises heating the crosslinked UHMWPE to a compression deformable temperature and then deforming the UHMWPE, to provide the wear resistant UHMWPE.

20. The method according to claim 19 , wherein the deforming is accomplished by extruding the heat-treated UHMWPE through a die.

21. A method of making an oxidation resistant UHMWPE for use in making a bearing component for a medical implant, the method comprising:
heat treating a consolidated UHMWPE by heating to 330° C. or higher while applying radial pressure and simultaneously leaving a longitudinal direction of the consolidated UHMWPE unconstrained, to form a UHMWPE product, wherein the UHMWPE product has less cavitation than a UHMWPE product made by a corresponding heat treatment free of the radial pressure;
doping the UHMWPE product with an antioxidant; and
homogenizing the doped UHMWPE by heating above room temperature, to provide the oxidation resistant UHMWPE.

22. The method according to claim 21 , comprising homogenizing at a temperature above the onset melting temperature of the UHMWPE.

23. The method according to claim 22 , comprising doping at a temperature above the onset melting temperature of the UHMWPE.

24. The method according to claim 21 , further comprising crosslinking the UHMWPE product before the doping step.

25. A method of processing UHMWPE for subsequent use in an artificial joint bearing component, comprising:
heat treating a consolidated UHMWPE by heating to 330° C. or higher while applying radial pressure and simultaneously leaving a longitudinal direction of the consolidated UHMWPE unconstrained, to form a UHMWPE product, wherein the UHMWPE product has less cavitation than a UHMWPE product made by a corresponding heat treatment free of the radial pressure;
crosslinking the UHMWPE product; and
mechanically deforming the crosslinked UHMWPE to reduce the concentration of free radicals resulting from the crosslinking, to provide the UHMWPE for subsequent use in the artificial joint bearing component.

26. The method according to claim 25 , wherein mechanically deforming comprises heating the crosslinked UHMWPE to a compression deformable temperature and applying deformation pressure.

27. The method according to claim 25 , wherein deforming comprises extruding through a die.

28. The method according to claim 25 , wherein the deforming step comprises triaxial compression.

Assignees

• Biomet Mfg Llc

Inventors

• Freedman Jordan H
• Schroeder David W

Classifications

• B29K2995/0094

  Geometrical properties · CPC title

• B29K2105/255

  Blocks or tablets · CPC title

• B29C2035/0877

  using electron radiation, e.g. beta-rays · CPC title

• B29L2031/06

  Rods, e.g. connecting rods {, rails, stakes (shafts B29L2031/75; poles, masts, posts B29L2031/766)} · CPC title

• B29B13/02

  by heating (B29B13/06, B29B13/08 take precedence) · CPC title