Functionalized media and methods of making and using therefor

Patent metadata

Field	Value
Publication number	US-9586192-B2
Application number	US-201514600296-A
Country	US
Kind code	B2
Filing date	Jan 20, 2015
Priority date	Jul 20, 2012
Publication date	Mar 7, 2017
Grant date	Mar 7, 2017

Abstract

Methods, compositions, devices and kits are provided herein for separating, scavenging, capturing or identifying a metal from a target using a medium or scaffold with a selenium-containing functional group. The medium or the scaffold including the selenium-containing functional group has affinity and specificity to metal ions or compounds having one or more metals, and efficiently separates, recovers, and scavenges of the metals from a target such as a sample, solution, suspension, or mixture.

First claim

What is claimed is:

1. A method for recovering, removing, or scavenging a metal from a target, the method comprising:
contacting the target containing the metal with a medium or a scaffold comprising a selenium-containing functional group which is linked to the medium by a sulfur-containing functional group selected from a thiol or a thiolate, whereby the selenium-containing functional group specifically binds to the metal and separates the metal from at least one remaining component in the target; and,
separating the medium or the scaffold from the target, wherein the target is a material selected from the group comprising of: an aqueous material, a reaction mixture, a complex material, and a biological sample.

2. The method according to claim 1 , wherein the metal is selected from the group comprising of: a toxic metal, a composite metal, a high value metal, a transition metal, a lanthanide metal, and an actinide metal, for example the metal is at least one selected from the group of: scandium, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, niobium, molybdenum, technetium, ruthenium, rhodium, palladium, silver, cadmium, hafnium, tantalum, tungsten, rhenium, osmium, iridium, platinum, gold, mercury, actinium, rutherfordium, dubnium, seaborgium, bohrium, hassium, meitnerium, darmstadtium, and roentgenium.

3. The method according to claim 1 , wherein the medium or the scaffold comprises silica or is covalently linked or immobilized to the selenium-containing functional group by at least one spacer wherein the spacer is selected from the group consisting of: (C 1 -C 18 )alkyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )heteroalkyl, (C 6 -C 10 )aryl, (C 1 -C 9 )heteroaryl, and (C 6 -C 10 )aryl(C 1 -C 6 )alkyl.

4. The method according to claim 1 , wherein contacting further comprises at least one step selected from the group of: stirring, sonicating, and filtering.

5. The method according to claim 1 , wherein, after contacting, the method further comprises washing or drying a resulting solid.

6. The method according to claim 1 , wherein the contacting comprises adding at least one solvent selected from the group consisting of: chloroform, dichloromethane, ethyl acetate, diethyl ether, acetic acid, hexane, toluene, ethanol, acetone, methanol, tetrahydrofuran, dimethyl sulfoxide, acetonitrile, and a combination thereof.

7. The method according to claim 1 , wherein prior to contacting, the method comprises reacting a selenium benzyl ester with at least one silane selected from the group comprising of: 3-mercaptopropyltrimethoxysilane, 3-hydroxypropyltrimethoxysilane, 3-glycidoxypropyltrimethoxysilane, n-butyltrimethoxysilane, and 3-cyanopropyltrimethoxysilane to form the resulting selenium containing functional group.

8. The method according to claim 1 , wherein the medium comprises an activated silica gel or the medium is selected from the group consisting of: silica, silica gel, an activated silica gel, alumina, polystyrene, agarose, modified polymeric resin, cellulose, magnesium silicate, dextran, and starch.

Assignees

• Univ Brown

Inventors

• Huang Yongsong
• Dillon James

Classifications

• B01J20/289 Primary

  bonded via a spacer · CPC title

• B01J20/3246

  having a well defined chemical structure · CPC title

• B01J20/103

  comprising silica · CPC title

• B01J20/3219

  involving a particular spacer or linking group, e.g. for attaching an active group · CPC title

• B01J20/3248

  the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such · CPC title