METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
US-2024076619-A1 · Mar 7, 2024 · US
Polypeptide hydrogels and uses related thereto
US9585915B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9585915-B2 |
| Application number | US-201514602839-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 22, 2015 |
| Priority date | Jan 23, 2014 |
| Publication date | Mar 7, 2017 |
| Grant date | Mar 7, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to compositions comprising a recombinant polypeptide comprising a cell signaling sequence, e.g., JAG-1 sequence, fused to a hydrogel polypeptide sequence. In certain embodiments, the disclosure relates to methods of cell culture on three dimensional scaffolds/hydrogels composed of self-assembling peptides disclosed herein.
First claim
Opening claim text (preview).
The invention claimed is: 1. A hydrogel comprising a recombinant polypeptide in combination with a hydrogel polypeptide, wherein the recombinant polypeptide comprises a cell signaling sequence, wherein the cells signal sequence comprises SEQ ID NO: 1, fused to a hydrogel polypeptide sequence, wherein the hydrogel polypeptide and the recombinant polypeptide are in a ratio of between 1:5 to 1:15 by weight, and wherein the hydrogel polypeptide and the recombinant peptide are 1.5% to 2.5% by weight to volume of the hydrogel. 2. The hydrogel of claim 1 comprising a saccharide at a concentration of between 100 nm to 500 mM. 3. The hydrogel of claim 1 comprising a buffer creating a pH of between 7.0 to 7.7. 4. The hydrogel of claim 1 , wherein the hydrogel further comprising a cardiac progenitor cell.
Assignees
Inventors
Classifications
- C12N5/0657Primary
Cardiomyocytes; Heart cells · CPC title
- A61K35/34Primary
Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes (vascular smooth muscle A61K35/44) · CPC title
Proteins · CPC title
containing domain for protein-protein interaction · CPC title
Notch; Delta; Jagged; Serrate · CPC title
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- What does patent US9585915B2 cover?
- This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to compositions comprising a recombinant polypeptide comprising a cell signaling sequence, e.g., JAG-1 sequence, fused to a hydrogel polypeptide sequence. In certain embodiments, the disclosure relates to me…
- Who is the assignee on this patent?
- Univ Emory, Georgia Tech Res Inst
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0657. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 07 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).