Hepatitis C virus inhibitors

Patent metadata

Field	Value
Publication number	US-9580463-B2
Application number	US-201414768229-A
Country	US
Kind code	B2
Filing date	Mar 3, 2014
Priority date	Mar 7, 2013
Publication date	Feb 28, 2017
Grant date	Feb 28, 2017

Abstract

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

First claim

What is claimed is:

1. A compound of formula (I)

or a pharmaceutically acceptable salt thereof, wherein
p is 1 or 2;
is a single or double bond;
m is 0, 1, or 2;
R 1 is

wherein R 1 is attached to the parent molecular moiety through any substitutable carbon atom in the ring;
n is 0, 1, 2, 3, 4, 5, or 6;
X 0 is selected from CH and N;
X 1 is selected from CH and N;
X 2 and X 3 are independently selected from CH, C(R a ) and N; provided that at least one of X 1 , X 2 , and X 3 is other than N;
each R a is independently selected from alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkyl, benzodioxanyl, carboxamido, carboxy, carboxyalkoxy, cyano, cycloalkyl, cycloalkylalkoxy, cycloalkyloxy, deuteroalkoxy, dialkylamino, halo, haloalkyl, haloalkoxy, haloalkoxycarbonyl, hydroxy, imidazolyl, morpholinyl, oxazolyl, phenyl, piperazinyl, pyrazolyl, pyridinyl, pyrrolidinyl, thiazolyl, and —NR q R q′ , wherein the imidazolyl, the morpholinyl, the oxazolyl, the phenyl, the piperazinyl, the pyridinyl, the pyrrolidinyl, and the thiazolyl are optionally substituted with one or two groups independently selected from alkoxy, alkyl, alkylsulfonyl, halo, haloalkoxy, haloalkyl, and morpholinyl; and wherein two adjacent R a groups, together with the carbon atoms to which they are attached, can optionally form a ring selected from dioxanyl, dioxolanyl, furanyl, morpholinyl, pyranyl, and phenyl, wherein the ring is optionally substituted with one or two groups independently selected from alkyl and halo;
R x is selected from hydrogen and methyl;
R 2 is selected from hydrogen, alkyl, deuteroalkyl, halo, haloalkoxy, haloalkyl, and hydroxyalkyl;
R 3 is selected from hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalkoxycarbonyl, deuterohaloalkoxycarbonyl, dialkylaminocarbonyl, dialkylaminocarbonylcarbonyl, haloalkoxycarbonyl, haloalkylaminocarbonyl, haloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, phenylcarbonyl, and phenyloxycarbonyl, wherein the cycloalkyl part of the cycloalkylalkoxycarbonyl, the cycloalkylcarbonyl, and the cycloalkyloxycarbonyl, the heterocyclyl part of the heterocyclylcarbonyl and the heterocyclyloxycarbonyl, and the phenyl part of the phenylcarbonyl and the phenyloxycarbonyl, is optionally substituted with one, two, or three groups independently selected from alkyl, alkylamino, alkylcarbonyl, cycloalkyl, dialkylamino, halo, haloalkoxy, and haloalkyl; and
one of R q and R q′ is selected from hydrogen and alkyl and the other is selected from alkylcarbonyl and phenylcarbonyl.

2. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein p is 1.

3. A compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein is a double bond.

4. A compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein m is 1.

5. A compound of claim 4 wherein R 1 is

wherein R 1 is attached to the parent molecular moiety through any substitutable carbon atom in the ring;
n is 1,
q is 0, 1, 2, 3, or 4;
X 0 is selected from CH and N;
X 1 is selected from CH and N;
X 2 and X 3 are independently selected from CH, C(R a ) and N; provided that at least one of X 1 , X 2 , and X 3 is other than N;
X 4 is selected from CH and CR a ;
each R a is independently selected from alkoxy, alkyl, halo, and haloalkyl.

6. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from hydrogen, alkyl, and haloalkyl.

7. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from alkoxycarbonyl and haloalkoxycarbonyl.

8. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
p is 1;
is a double bond;
m is 1; and
R 1 is

wherein
wherein R 1 is attached to the parent molecular moiety through any substitutable carbon atom in the ring;
n is 1,
q is 0, 1, 2, 3, or 4;
X 0 is selected from CH and N;
X 1 is selected from CH and N;
X 2 and X 3 are independently selected from CH, C(R a ) and N; provided that at least one of X 1 , X 2 , and X 3 is other than N;
X 4 is selected from CH and CR a ; and
each R a is independently selected from alkoxy, alkyl, halo, and haloalkyl.

9. A compound selected from
tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
1,1,1-trifluoro-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
1,1,1-trifluoro-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate
1,1,1-trifluoro-2-methylpropan-2-yl ((2R,6S,7R,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
1,1,1-trifluoro-2-methylpropan-2-yl ((2R,6S,7R,13aS,14aR,16aS,Z)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-1-yl)oxy)-7-(methoxymethyl)-9-methyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate;
tert-butyl (

Assignees

• Bristol Myers Squibb Co

Inventors

• Nagalakshmi Pulicharla
• Sarkunam Kandhasamy
• Renduchintala Kishore V
• Scola Paul Michael

Classifications

• A61K38/06

  Tripeptides · CPC title

• C07K5/081 Primary

  the side chain containing O or S as heteroatoms, e.g. Cys, Ser · CPC title

• A61K38/07

  Tetrapeptides · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61P31/22

  for herpes viruses · CPC title