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PET/SPECT agents for applications in biomedical imaging
US9579408B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9579408-B2 |
| Application number | US-201213984723-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 10, 2012 |
| Priority date | Feb 11, 2011 |
| Publication date | Feb 28, 2017 |
| Grant date | Feb 28, 2017 |
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- Title
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Abstract
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Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67 Ga or 68 Ga. Methods of synthesizing the tracers, and methods of imaging heart and other tissues are also disclosed. The tracers can be used to obtain high signal-to-background ratios for imaging tissues in vivo such as heart or tumor tissue. In various embodiments, disclosed tracers can exhibit, a) enhanced first pass extraction into heart tissue compared to presently available probes, b) linearity with true blood flow, c) enhanced detection of myocardial viability compared to presently available probes, d) reduced liver retention compared to presently available probes, and e) more efficient clearance from non-cardiac and adjoining tissues compared to presently available probes.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound comprising a structure Wherein each of R 1 and R 2 is H; each of R 7 and R 8 is methyl; each R 3 is isopropoxy; each of R 4 , R 5 and R 6 is H; and each R 9 is H. 2. A salt of structure wherein A− is an anion. 3. The salt in accordance with claim 2 , wherein the anion is an I − . 4. The salt in accordance with claim 2 , wherein the Ga + is a 67 Ga + . 5. The salt in accordance with claim 2 , wherein the Ga + is a 68 Ga + . 6. The salt in accordance with claim 2 , wherein the anion is an I − and the Ga + is a 68 Ga + .
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Classifications
containing trace elements · CPC title
- A61K51/0478Primary
complexes from non-cyclic ligands, e.g. EDTA, MAG3 · CPC title
Heterocyclic compounds · CPC title
Acyclic or carbocyclic compounds · CPC title
- C07C251/24Primary
having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings · CPC title
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- What does patent US9579408B2 cover?
- Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67 Ga or 68 Ga. Methods of synthesizing the tracers, and methods of imaging heart and other tissues are also disclosed. The tracers can be used to obtain high signal-to-background ratios for imaging tissues in vivo such as …
- Who is the assignee on this patent?
- Sharma Vijay, Sivapackiam Jothilingam, Piwnica-Worms David, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K51/0478. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 28 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).