Compositions containing polysaccharides

Patent metadata

Field	Value
Publication number	US-9579303-B2
Application number	US-88443306-A
Country	US
Kind code	B2
Filing date	Feb 14, 2006
Priority date	Feb 15, 2005
Publication date	Feb 28, 2017
Grant date	Feb 28, 2017

Abstract

The disclosure relates to compositions, preferably in the form of a powder and/or granules, which contain as principal components a first component selected from the group consisting of isoflavones, soy products containing at least one isoflavone, and mixtures thereof, together with a polysaccharide as second component. A preferred first component is genistein or a pharmaceutically acceptable salt or derivative thereof (e.g. genistin). A preferred second component is pectin. The disclosure further relates to a process for the manufacture of such compositions, and their use in dietary supplements, pharmaceutical and personal care compositions. The disclosure is also directed to the use of a polysaccharide for improving the flowability of a component selected from the group consisting of isoflavones, soy products, preferably those containing at least one isoflavone, and mixtures thereof.

First claim

The invention claimed is:

1. A method of improving the flowability of a powder consisting of isoflavone; said method consisting of introducing water-soluble pectin into the powder.

2. The method according to claim 1 wherein the isoflavone is an isoflavone of formula I, a pharmaceutically acceptable salt or a glycoside thereof, wherein formula I is:

wherein R signifies hydrogen, C 1-18 -alkyl or C 1-18 alkylcarbonyl, R 1 signifies hydrogen or hydroxyl or C 1-18 -alkyloxy or C 1-18 -alkylcarbonyloxy, and R 2 signifies hydroxyl or C 1-18 -alkoxy or C 1-18 -alkylcarbonyloxy.

3. The method according to claim 2 , wherein R is hydrogen and R 1 and R 2 are both hydroxyl.

4. The method of claim 1 , wherein the water-soluble pectin is introduced in the form of a slurry.

5. The method of claim 4 , wherein the slurry is an aqueous slurry.

6. A composition consisting of a powder or a plurality of granules, said powder or plurality of granules consisting of:
a) a first component which is isoflavone in a quantity of 95-99.9 weight %; and
b) a second component which is pectin in a quantity of 0.1-5 weight-%.

7. The composition of claim 6 , wherein the isoflavone in the powder, or in the plurality of granules, is coated or partially coated with the pectin.

8. The composition according to claim 6 , wherein the isoflavone is selected from the group consisting of isoflavones of formula I, pharmaceutically acceptable salts or glycosides thereof wherein formula I is:

wherein R signifies hydrogen, C 1-18 -alkyl or C 1-18 alkylcarbonyl, R 1 signifies hydrogen or hydroxyl or C 1-18 -alkyloxy or C 1-18 -alkylcarbonyloxy, and R 2 signifies hydroxyl or C 1-18 -alkoxy or C 1-18 -alkylcarbonyloxy.

9. The composition of claim 8 , wherein the isoflavone in the powder, or in the plurality of granules, is coated or partially coated with the pectin.

10. The composition according to claim 8 , wherein R is hydrogen and R 1 and R 2 are both hydroxyl.

11. The composition of claim 10 , wherein the isoflavone in the powder, or in the plurality of granules, is coated or partially coated with the pectin.

12. The composition of claim 6 in a dosage form selected from the group consisting of a tablet, and capsule.

13. The dosage form according to claim 12 , wherein the dosage form is a tablet.

14. A dietary, pharmaceutical and personal care composition comprising a composition as claimed in claim 6 .

15. A process for the manufacture of a composition according to claim 6 , which comprises preparing a slurry of the-components having a solid content of 10 to 70% by weight, based on the total weight of the slurry, and spray-drying the slurry.

16. The process of claim 15 , wherein the slurry has a solid content of 25 to 50% by weight.

17. A process for the manufacture of a composition according to claim 6 , which comprises forming a fluidized bed of the first component with or without pectin within a fluidized-bed drying device fitted with spray means, said fluidized bed being fluidized by air or an inert gas, and spraying a solution, of a pectin or only water in the form of an atomized mist onto the fluidized particles until the composition is obtained.

18. The process according to claim 15 or 17 , wherein the first component is an isoflavone of the formula I,

wherein R signifies hydrogen, C 1-18 -alkyl or C 1-18 alkylcarbonyl, R 1 signifies hydrogen or hydroxyl or C 1-18 -alkyloxy or C 1-18 -alkylcarbonyloxy, and R 2 signifies hydroxyl or C 1-18 -alkoxy or C 1-18 -alkylcarbonyloxy, or a pharmaceutically acceptable salt or glycoside thereof.

19. The process according to claim 18 , wherein R is hydrogen and R 1 and R 2 are both hydroxyl.

20. A process for the manufacture of a composition according to claim 6 , which comprises forming a fluidized bed of the first component within a fluidized-bed drying device fitted with spray means, said fluidized bed being fluidized by air or an inert gas, and spraying an aqueous solution of a pectin and water in the form of an atomized mist onto the fluidized particles until the composition is obtained.

Assignees

• Chen Chyi-Cheng
• Leuenberger Bruno H
• Dsm Ip Assets Bv

Inventors

• Chen Chyi-Cheng
• Leuenberger Bruno H

Classifications

• A61P35/00

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• A61P9/00

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• A61P5/30

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• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/06

  Antimigraine agents · CPC title