Emulsion-derived particles

Patent metadata

Field	Value
Publication number	US-9574054-B2
Application number	US-201514945002-A
Country	US
Kind code	B2
Filing date	Nov 18, 2015
Priority date	Oct 29, 2007
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

An emulsion-derived particle comprises a lattice of polymeric strands cross-linked by means of a cross-linking agent, and interstitial openings adjacent and around the strands. Functional groups are provided on the lattice and proteins and/or modified proteins can react with these, thereby to be bonded to the lattice and hence immobilized.

First claim

That which is claimed:

1. A process for producing particles, which includes allowing, in an emulsion, across-linking agent to cross-link polyethyleneimine strands, thereby forming particles, each particle comprising a lattice of the polyethyleneimine strands cross-linked by means of the cross-linking agent, interstitial openings adjacent and around the polyethyleneimine strands, and aldehyde functional groups on the lattice with which proteins and/or modified proteins can react, thereby to be bonded to the lattice and hence immobilized, with the particles hence being emulsion derived.

2. A process according to claim 1 , wherein the polyethyleneimine and the cross-linking agent are present in a dispersed phase of the emulsion.

3. A process according to claim 1 , wherein the cross-linking agent is present in a continuous phase of the emulsion.

4. A process according to claim 1 , wherein the polyethyleneimine and cross-linking agent are provided in separate dispersed phases in the emulsion.

5. A process according to claim 1 , wherein the polyethyleneimine and cross-linking agent are mixed prior to dispersion in a continuous phase of the emulsion.

6. A process according to claim 1 , which includes adding an adjunct to at least one phase of the emulsion, so that the adjunct is entrapped within the lattices of the particles.

7. A process according to claim 1 , which includes recovering the particles and drying the recovered particles.

8. A process according to claim 7 , which includes adding an adjunct to the recovered particles before the drying of the particles, so that the adjunct becomes entrapped within the lattices of the particles.

9. A process for producing particles, which includes allowing, in an emulsion, a cross-linking agent to cross-link polyethyleneimine strands, thereby forming particles, each particle comprising a support lattice of the polyethyleneimine strands cross-linked by means of the cross-linking agent, with the polyethyleneimine strands thus forming a network backbone of the support lattice, interstitial openings adjacent and around the strands, and aldehyde functional groups on the support lattice with which proteins and/or modified proteins can react, thereby to be bonded to the support lattice and hence immobilized, with the particles hence being emulsion derived.

Assignees

• Csir

Inventors

• Jordaan Justin
• Simpson Clinton
• Brady Dean
• Gardiner Neil Stockenstrom
• Gerber Isak Bartholomeus

Classifications

• C08J3/24

  Crosslinking, e.g. vulcanising, of macromolecules (mechanical aspects B29C35/00; crosslinking agents C08K) · CPC title

• C08J3/005

  Processes for mixing polymers · CPC title

• C07K17/08

  the carrier being a synthetic polymer · CPC title

• C12N11/06

  attached to the carrier via a bridging agent · CPC title

• C08J3/16 Primary

  by coagulating dispersions {(C08J3/122 takes precedence)} · CPC title