Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases

Patent metadata

Field	Value
Publication number	US-9573939-B2
Application number	US-201214343462-A
Country	US
Kind code	B2
Filing date	Aug 16, 2012
Priority date	Sep 8, 2011
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

First claim

The invention claimed is:

1. A compound having the structure:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

3. The pharmaceutical composition of claim 2 , further comprising a second therapeutic agent selected from the group consisting of HCV antiviral agents, immunomodulators, and anti-infective agents.

4. The pharmaceutical composition of claim 3 , wherein the second therapeutic agent is selected from the group consisting of HCV protease inhibitors, HCV NS5A inhibitors and HCV NS5B polymerase inhibitors.

5. A method of treating a patient infected with HCV, the method comprising administering to the patient the compound of claim 1 , or a pharmaceutically acceptable salt thereof, in an amount effective to prevent and/or treat infection by HCV in the patient.

6. The method of claim 5 , further comprising the step of administering pegylated-interferon alpha and ribavirin to the patient.

Assignees

• Mccomas Casey C
• Liverton Nigel J
• Habermann Joerg
• Koch Uwe
• Narjes Frank
• Li Peng
• Peng Xuanjia
• Soll Richard
• Wu Hao
• Palani Anandan
• Dai Xing
• Liu Hong
• He Shuwen
• Dang Qun
• Merck Sharp & Dohme
• Msd Italia Srl

Inventors

• Mccomas Casey C
• Liverton Nigel J
• Habermann Joerg
• Koch Uwe
• Narjes Frank
• Li Peng
• Peng Xuanjia
• Soll Richard
• Wu Hao
• Palani Anandan
• Dai Xing
• Liu Hong
• He Shuwen
• Dang Qun

Classifications

• A61P31/14

  for RNA viruses · CPC title

• A61P31/12

  Antivirals · CPC title

• A61K31/4184

  condensed with carbocyclic rings, e.g. benzimidazoles · CPC title

• A61K31/4439

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• A61K31/4045

  Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin · CPC title