Cartridge for dispensing a fluid comprising a reagent

Patent metadata

Field	Value
Publication number	US-9573131-B2
Application number	US-201414530857-A
Country	US
Kind code	B2
Filing date	Nov 3, 2014
Priority date	May 8, 2012
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.

First claim

We claim:

1. A cartridge for dispensing a fluid, the cartridge comprising:
a reservoir chamber for receiving the fluid and for receiving a ventilation gas, wherein the reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid, wherein at least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position, wherein the inlet is located in the portion filled with the ventilation gas, and wherein the fluid comprises a reagent; and
a baffle for restricting gas diffusion through the inlet, wherein the reservoir chamber receives the ventilation gas via the baffle, wherein the inlet is attached to the baffle and maintains a constant gas pressure within the portion of the reservoir chamber that is filled with the ventilation gas, and wherein the baffle is adjacent to and at least partially formed on an exterior surface of the cartridge.

2. The cartridge of claim 1 , wherein the inlet maintains a constant gas pressure within the portion of the reservoir chamber that is filled with the ventilation gas when the reservoir chamber is between 10 percent and 90 percent full with the fluid.

3. The cartridge of claim 1 , wherein the inlet maintains a constant gas pressure within the portion of the reservoir chamber that is filled with the ventilation gas when the reservoir chamber is between 20 percent and 80 percent full with the fluid.

4. The cartridge of claim 1 , wherein the dispenser dispenses fluid at a rate independent of the baffle.

5. The cartridge of claim 1 , further comprises,
a cap for sealing the inlet.

6. The cartridge of claim 5 , wherein the cap moves to an open position to open the inlet.

7. The cartridge of claim 6 , wherein the cap re-seals the inlet.

8. The cartridge of claim 5 , wherein the cartridge forms at least a portion of the baffle when the cap is opened.

9. The cartridge of claim 5 , wherein the cartridge comprises threads for attaching the cap.

10. The cartridge of claim 9 , wherein the baffle comprises a diffusion path formed in the threads.

11. The cartridge of claim 10 , wherein the diffusion path comprises a channel in the threads, and wherein the cartridge further comprises a cap restraint for limiting the opening of the cap a predetermined amount.

12. The cartridge of claim 5 , wherein the baffle comprises a tube located at least partially within the reservoir chamber, wherein the tube comprises an opening and the inlet, and wherein the cap seals the inlet within the reservoir chamber.

13. The cartridge of claim 5 , wherein the cap is attached to cartridge.

14. The cartridge of claim 5 , wherein the cap is removable from the cartridge.

15. The cartridge of claim 5 , wherein the cap is movable between an open position and a closed position, and wherein when in the open position, the cap opens the baffle.

16. The cartridge of claim 1 , wherein the baffle comprises a tube located at least partially within the reservoir chamber.

17. The cartridge of claim 1 , wherein the baffle comprises a tube mounted on the exterior surface.

18. The cartridge of claim 1 , wherein the baffle is at least partially formed within the reservoir chamber.

19. The cartridge of claim 1 , wherein at least a part of the cartridge is injection molded, and wherein the baffle is formed at least partially by the part.

20. The cartridge of claim 1 , wherein the baffle comprises a gas filter.

21. The cartridge of claim 1 , further comprises,
the fluid.

22. The cartridge of claim 1 , wherein the fluid comprises any one of the following: a blood grouping reagent, a solvent, a diluent, a catalyst, an antibody, an enzyme, a recombinant protein, a virus isolate, a virus, a biological reagent, a protein, a salt, a detergent, a nucleic acid, an acid, a base, a dispersion, latex particles, nano particles, magnetic particles, and combinations thereof.

23. The cartridge of claim 1 , further comprises,
a dispenser for dispensing the fluid, and wherein the dispenser receives the fluid from the outlet.

24. The cartridge of claim 23 , wherein the dispenser is a micro-fluidic dispensing assembly.

25. The cartridge of claim 23 , wherein the dispenser dispenses any one of the following: volumes less than 10 μL, less than 500 nL, less than 200 nL, less than 100 nL, and less than 20 nL.

Assignees

• Roche Diagnostics Operations Inc

Inventors

• Brueckner Thorsten
• Koltay Peter
• Oranth Norbert
• Spinke Juergen
• Tanguy Laurent

Classifications

• Y10T436/11

  Automated chemical analysis · CPC title

• B01L3/52 Primary

  Containers specially adapted for storing or dispensing a reagent (B01L3/02 takes precedence; storing or dispensing test elements G01N33/4875; automated reagent dispensing G01N35/1002) · CPC title

• B01L2400/086

  using baffles or other fixed flow obstructions · CPC title

• B01L2200/141

  Preventing contamination, tampering · CPC title

• B01L3/523

  with means for closing or opening · CPC title