Graphene-based filter for isolating a substance from blood

Patent metadata

Field	Value
Publication number	US-9572918-B2
Application number	US-201313923503-A
Country	US
Kind code	B2
Filing date	Jun 21, 2013
Priority date	Jun 21, 2013
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

A device isolates a substance from blood. The substance includes particles with an effective diameter that is within a range defined by effective diameters of constituents of blood. The device comprises a first sheet of graphene including a first plurality of apertures. The first plurality of apertures are configured to pass objects with an effective diameter less than or equal to the effective diameter of the particles of the substance. The device comprises a second sheet of graphene including a second plurality of apertures. The second plurality of apertures are configured to pass objects with an effective diameter less than the effective diameter of the particles of the substance. The device may be configured to include a conduit system. The device may be configured to operate according to a reversible cycle.

First claim

What is claimed is:

1. A method for isolating glucose from blood, the method comprising:
regulating the flow of the blood through a first sheet of graphene and a second sheet of graphene,
wherein the first sheet of graphene comprises a first plurality of apertures with an effective diameter that allows passage of glucose across the first sheet of graphene; and
wherein the second sheet of graphene comprises a second plurality of apertures with an effective diameter less than the effective diameter of glucose.

2. The method of claim 1 , wherein the first plurality of apertures comprises apertures with a nominal diameter of at least 0.74 nanometers and the second plurality of apertures comprises apertures with a nominal diameter less than 0.70 nanometers.

3. The method of claim 2 , wherein the first plurality of apertures comprises apertures that are nominally spaced 2 nanometers center-to-center.

4. The method of claim 3 , wherein the second plurality of apertures comprises apertures that are nominally spaced 2 nanometers center-to-center.

5. The method of claim 2 , wherein regulating the flow of the blood through the first sheet of graphene and the second sheet of graphene includes circulating blood from a source through a conduit system.

6. The method of claim 2 , wherein regulating the flow of the blood through the first sheet of graphene and the second sheet of graphene includes using a reversible cycle.

7. The method of claim 5 , wherein said regulation is with a device that comprises a plurality of pressure release valves configured to regulate the flow of the blood from the conduit system to the source.

8. The method of claim 6 , wherein regulating the flow of the blood through the first sheet of graphene and the second sheet of graphene includes using a mechanical system comprising a piston disposed within a cylinder, wherein the piston is configured to circulate blood from a source through the cylinder.

9. The method of claim 8 , wherein the mechanical system further includes a plurality of controllable valves, and wherein isolating the glucose using the reversible cycle includes drawing blood from the source through the first sheet of graphene and into the cylinder.

10. The method of claim 9 , wherein isolating the glucose using the reversible cycle further includes returning blood from the cylinder to the source through the second sheet of graphene.

11. The method of claim 1 , wherein the first plurality of apertures is approximately 2% to 25% larger than the effective diameter of glucose.

12. The method of claim 1 , wherein the second plurality of apertures is approximately 2% to 25% smaller than the effective diameter of glucose.

13. The method of claim 1 , wherein the diameter of the first plurality of apertures and the diameter of the second plurality of apertures differ by about 0.04 nanometers.

14. The method of claim 5 , wherein the conduit system is a two stage bypass filter.

15. The method of claim 1 , wherein the first sheet of graphene and the second sheet of graphene are configured in a medical device.

16. The method of claim 15 , wherein the medical device is an implantable medical device.

17. The method of claim 1 , wherein the first sheet of graphene, the second sheet of graphene or both are coupled with one or more additional sheets of graphene to form multiple sheet graphene membranes.

18. The method of claim 1 , wherein the first sheet of graphene, the second sheet of graphene or both are coupled with one or more diamond membranes.

19. The method of claim 1 , further comprising returning the blood that flowed through the first sheet of graphene and the second sheet of graphene to its source.

20. The method of claim 1 , wherein the first plurality of apertures comprises apertures that are approximately 2% to 25% larger than the effective diameter of glucose, and wherein the second plurality of apertures comprises apertures that are approximately 2% to 25% smaller than the effective diameter of glucose.

21. The method of claim 1 , wherein the first plurality of apertures comprises apertures that are approximately 2% larger than the effective diameter of glucose, and wherein the second plurality of apertures comprises apertures that are approximately 2% smaller than the effective diameter of glucose.

22. The method of claim 1 , wherein the first plurality of apertures comprises apertures with a nominal diameter of approximately 0.74 nm, and wherein the second plurality of apertures comprises apertures with a nominal diameter of approximately 0.70 nm.

23. A method for isolating glucose from blood, the method comprising:
passing blood through a first sheet of graphene and a second sheet of graphene,
wherein the first sheet of graphene comprises a first plurality of apertures with a nominal diameter of approximately 0.74 nm, and
wherein the second sheet of graphene comprises a second plurality of apertures with a nominal diameter of approximately 0.70 nm,
to thereby isolate the glucose from the blood.

24. The method of claim 23 , wherein the first sheet of graphene consists of a first plurality of apertures with a nominal diameter of approximately 0.74 nm, and wherein the second sheet of graphene consists of a second plurality of apertures with a nominal diameter of approximately 0.70 nm.

25. A method for isolating glucose from blood, the method comprising:
passing blood through a first sheet of graphene and a second sheet of graphene,
wherein the first sheet of graphene comprises a first plurality of apertures with a nominal diameter of at least 0.74 nm, and
wherein the second sheet of graphene comprises a second plurality of apertures with a nominal diameter of less than 0.70 nm,
to thereby isolate the glucose from the blood.

26. The method of claim 21 , wherein the first plurality of apertures have a nominal diameter of from 0.74 nm to 0.9 nm.

27. The method of claim 21 , wherein the second plurality of apertures have a nominal diameter of from 0.54 nm to 0.7 nm.

Assignees

• Lockheed Corp

Inventors

• Bachmann Svetlana Monakhova
• Mountcastle Paul Declan
• Tietjen Byron W

Classifications

• A61M1/36

  Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation {; Extra-corporeal blood circuits} · CPC title

• A61M1/34 Primary

  Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration · CPC title

• A61K35/14

  Blood; Artificial blood (perfluorocarbons A61K31/02; umbilical cord blood A61K35/51; haemoglobin A61K38/42) · CPC title

• B01D61/02

  Reverse osmosis; Hyperfiltration {; Nanofiltration} · CPC title

• A61M2202/0014

  removed from the body · CPC title