Boron-containing small molecules
US-2015119364-A1 · Apr 30, 2015 · US
Boron-containing small molecules
US9572823B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9572823-B2 |
| Application number | US-201615091394-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 5, 2016 |
| Priority date | Feb 16, 2005 |
| Publication date | Feb 21, 2017 |
| Grant date | Feb 21, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of delivering a compound, in a human, from a dorsal layer of a nail plate to a nail bed to treat onychomycosis caused by Trichophyton rubrum or Trichophyton mentagrophytes , the method comprising: contacting the dorsal layer of the nail plate with a pharmaceutical composition comprising a compound that penetrates the nail plate, the compound being 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt thereof, thereby treating onychomycosis due to Trichophyton rubrum or Trichophyton mentagrophytes. 2. The method of claim 1 , wherein the pharmaceutical composition is in the form of a topical solution comprising 5% w/w of 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole, and wherein the pharmaceutical composition further comprises ethanol and propylene glycol. 3. The method of claim 1 , wherein the pharmaceutical composition further comprises ethanol and propylene glycol. 4. The method of claim 1 , wherein the contacting of the dorsal layer of the nail plate with the pharmaceutical composition occurs once a day. 5. The method of claim 1 , wherein a cause of the onychomycosis is due to Trichophyton rubrum. 6. The method of claim 1 , wherein a cause of the onychomycosis is due to Trichophyton mentagrophytes.
Assignees
Inventors
Classifications
Antimycotics · CPC title
Boron compounds · CPC title
- C07F5/025Primary
Boronic and borinic acid compounds · CPC title
Drugs for dermatological disorders · CPC title
Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12 (esters with inorganic acids C07H11/00) · CPC title
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- What does patent US9572823B2 cover?
- This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by …
- Who is the assignee on this patent?
- Anacor Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification C07F5/025. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 21 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).