Treatment of cervical cancer with gold(I) complexes

Patent metadata

Field	Value
Publication number	US-9572822-B2
Application number	US-201615282716-A
Country	US
Kind code	B2
Filing date	Sep 30, 2016
Priority date	Mar 19, 2014
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

Gold(I) complexes of formulae [Au{P(t-Bu) 3 }(S 2 CN(CH 3 ) 2 )] (1), and [Au{P(t-Bu) 3 }(S 2 CN(C 2 H 5 ) 2 )] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu) 3 }(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.

First claim

The invention claimed is:

1. A method for treating cancer or a tumor comprising administering, in a cytotoxically effective amount, a gold complex of formula:
Au{P(t-Bu) 3 }(S 2 CN(R) 2 )
where R is CH 3 or C 2 H 5 ,
to a subject in need of treatment for a human cervical cancer,
wherein the gold complex is administered in the form of a solution.

2. The method of claim 1 , wherein the gold complex is administered in the form of a solution in the presence of fetal bovine serum.

Assignees

• Univ King Fahd Pet & Minerals
• King Abdulaziz City Sci & Tech

Inventors

• Isab Anvarhusein Abdulkadir
• Altaf Muhammad
• Monim-Ul-Mehboob Muhammad
• Seliman Adam Ahmed Abdallah
• Wazeer Mohammed Ismail

Classifications

• C07F9/5045 Primary

  Complexes or chelates of phosphines with metallic compounds or metals · CPC title

• A61K31/66 Primary

  Phosphorus compounds · CPC title

• G01N33/5011

  for testing antineoplastic activity · CPC title

• G01N33/5044

  involving specific cell types · CPC title