Tissue thickness compensators comprising therapeutic agents

Patent metadata

Field	Value
Publication number	US-9572574-B2
Application number	US-201514746373-A
Country	US
Kind code	B2
Filing date	Jun 22, 2015
Priority date	Sep 30, 2010
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

An end effector is disclosed. The end effector comprises a first jaw, a second jaw, wherein at least one of the first jaw and the second jaw is movable to compress tissue between the first jaw and the second jaw, and a cartridge body configured to receive a cutting member. The end effector further comprises a layer arrangement including a tissue contact surface and a plurality of therapeutic agents releasably contained within the layer arrangement, wherein each therapeutic agent is configured to either initially treat the tissue or sustainably treat the tissue in contact with the tissue contact surface, wherein one of the plurality of therapeutic agents is configured to be released by the cutting member, and wherein another of the plurality of therapeutic agents is configured to be released by an absorption process.

First claim

What is claimed is:

1. An end effector, comprising:
a first jaw;
a second jaw, wherein at least one of said first jaw and said second jaw is movable to compress tissue between said first jaw and said second jaw;
a cartridge body configured to receive a cutting member;
a compensator including a tissue contact surface;
a first therapeutic agent releasably contained within said compensator, wherein said first therapeutic agent is configured to initially treat the tissue in contact with said tissue contact surface, and wherein said first therapeutic agent is configured to be released by the cutting member; and
a second therapeutic agent releasably contained within said compensator, wherein said second therapeutic agent is configured to sustainably treat the tissue in contact with said tissue contact surface, wherein said second therapeutic agent is configured to be released by an absorption process, and wherein said second therapeutic agent is different than said first therapeutic agent.

2. The end effector of claim 1 , further comprising:
a first pocket defined in said tissue contact surface, wherein said first pocket is configured to release said first therapeutic agent; and
a second pocket defined in said tissue contact surface, wherein said second pocket is configured to release said second therapeutic agent.

3. The end effector of claim 2 , further comprising the cutting member, wherein said compensator further includes a longitudinal axis defining a cutting path for said cutting member on said tissue contact surface, wherein said first pocket extends across said longitudinal axis, and wherein said second pocket does not extend across said longitudinal axis.

4. The end effector of claim 2 , wherein said first pocket is one of a plurality of first pockets defined in said tissue contact surface, and wherein said second pocket is one of a plurality of second pockets defined in said tissue contact surface.

5. The end effector of claim 4 , wherein said compensator further comprises a longitudinal axis, and wherein said first pockets and said second pockets extend across said longitudinal axis.

6. The end effector of claim 4 , wherein said first pockets and said second pockets are arranged on said tissue contact surface in a pattern.

7. The end effector of claim 4 , further comprising:
a means for releasing said first therapeutic agent from a said first pocket; and,
a means for releasing said second therapeutic agent from a said second pocket.

8. The end effector of claim 7 , wherein said means for releasing said second therapeutic agent is different than said means for releasing said first therapeutic agent.

9. The end effector of claim 1 , wherein said first therapeutic agent comprises a hemostatic agent.

10. The end effector of claim 1 , wherein said first therapeutic agent comprises an anti-inflammatory agent.

11. The end effector of claim 1 , wherein said second therapeutic agent comprises an antimicrobial agent.

12. The end effector of claim 1 , wherein said second therapeutic agent comprises an anticancer agent.

13. An end effector, comprising:
a first jaw;
a second jaw, wherein at least one of said first jaw and said second jaw is movable to compress tissue between said first jaw and said second jaw;
a layer assembly including a tissue contact surface;
a cartridge body configured to receive a cutting member;
a first medicament releasably held within said layer assembly, wherein said first medicament is configured to initially treat the tissue in contact with said tissue contact surface, and wherein said first medicament is configured to be released by the cutting member; and
a second medicament releasably held within said layer assembly, wherein said second medicament is configured to sustainably treat the tissue in contact with said tissue contact surface, and wherein said second medicament is configured to be released by an absorption process.

14. The end effector of claim 13 , wherein said second medicament is different than said first medicament.

15. The end effector of claim 13 , wherein said layer assembly comprises a first layer and a second layer, wherein said first layer and said second layer define a first packet and a second packet in said tissue contact surface, wherein said first packet is configured to release said first medicament, and wherein said second packet is configured to release said second medicament.

16. The end effector of claim 15 , wherein said first packet is one of a plurality of first packets defined in said tissue contact surface, and wherein said second packet is one of a plurality of second packets defined in said tissue contact surface.

17. The end effector of claim 16 , wherein said layer assembly further comprises a longitudinal axis, a proximal end, and a distal end, and wherein said first packets and said second packets extend across said longitudinal axis from said proximal end to said distal end.

18. The end effector of claim 17 , wherein said first packets and said second packets are arranged on said tissue contact surface in a pattern.

19. An end effector, comprising:
a first jaw;
a second jaw, wherein at least one of said first jaw and said second jaw is movable to compress tissue between said first jaw and said second jaw;
a layer assembly including a tissue contact surface;
a first medicament releasably held within said layer assembly, wherein said first medicament is configured to initially treat the tissue in contact with said tissue contact surface; and
a second medicament releasably held within said layer assembly, wherein said second medicament is configured to sustainably treat the tissue in contact with said tissue contact surface;
wherein said layer assembly comprises a first layer and a second layer, wherein said first layer and said second layer define a first packet and a second packet in said tissue contact surface, wherein said first packet is configured to release said first medicament, wherein said second packet is configured to release said second medicament, wherein said first packet is one of a plurality of first packets defined in said tissue contact surface, wherein said second packet is one of a plurality of second packets defined in said tissue contact surface, and wherein said first packets and said second packets are configured to release said first medicament and said second medicament respectively by rupturing when the tissue is compressed.

20. An end effector, comprising:
a first jaw;
a second jaw, wherein at least one of said first jaw and said second jaw is movable to compress tissue between said first jaw and said second jaw;
a layer assembly including a tissue contact surface;
a first medicament releasably held within said layer assembly, wherein said first medicament is configured to initially treat the tissue in contact with said tissue contact surface; and
a second medicament releasably held within said layer assembly, wherein said second medicament is configured to sustainably treat the tissue in contact with said tissue contact surface;
wherein said layer assembly comprises a first layer and a second layer, wherein said first layer and said second layer define a first packet and a second packet in said tissue contact surface, wherein said first packet is configured to release said first medicament, wherein said second packet is configured to release said second medicament, wherein said first packet is one of a plurality of first packets defined in said tissue contact surface, and wherein said second pack

Assignees

• Ethicon Endo Surgery Llc

Inventors

• Shelton Iv Frederick E
• Schmid Katherine J
• Scheib Charles J
• Aronhalt Taylor W
• Swayze Jeffrey S
• Contiliano Joseph H
• Yang Chunlin
• Henderson Cortney E
• Aldridge Jeffrey L

Classifications

• A61B2017/2916

  pins in guiding slots · CPC title

• A61B17/0643 Primary

  with separate closing member, e.g. for interlocking with staple · CPC title

• A61B2017/07228

  Arrangement of the staples · CPC title

• A61B2017/00991

  Telescopic means · CPC title

• A61B2017/00893

  pharmaceutically effective · CPC title