Short beta-defensin-derived peptides

Patent metadata

Field	Value
Publication number	US-9567371-B2
Application number	US-201514880238-A
Country	US
Kind code	B2
Filing date	Oct 11, 2015
Priority date	Feb 11, 2009
Publication date	Feb 14, 2017
Grant date	Feb 14, 2017

Abstract

The invention is directed to β-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.

First claim

What is claimed is:

1. A cyclized peptide having the sequence of
1,10-cyclo[RGRKCCRRKK], (cTL-1, SEQ ID NO: 3), wherein the arginine at position 1 is linked through a peptide bond to the lysine at position 10.

2. A pharmaceutical composition containing an effective amount of the peptide of claim 1 , and one or more pharmaceutically accepted carriers, excipients or diluents.

3. A method for reducing or inhibiting cancer metastasis in a subject in need thereof, comprising administering to the subject an effective amount of a peptide as set forth in claim 1 .

4. The method of claim 3 , wherein the subject is afflicted with a tumor characterized by CXCR4 expression of at least a portion of the tumor cells.

5. The method of claim 4 , wherein the tumor is of hematopoietic origin.

6. The method of claim 4 , wherein the tumor is leukemia.

7. The peptide of claim 1 being up to 16 amino acids in length.

8. A method for reducing or inhibiting cancer metastasis in a subject in need thereof, comprising administering to the subject an effective amount of a peptide as set forth in claim 7 .

Assignees

• Yeda Res & Dev

Inventors

• Lapidot Tsvee
• Kalinkovich Alexander
• Fridkin Matityahu

Classifications

• A61K38/1729 Primary

  Cationic antimicrobial peptides, e.g. defensins · CPC title

• A61K38/193

  Colony stimulating factors [CSF] · CPC title

• A61K38/12

  Cyclic peptides {, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C (A61K38/043 - A61K38/046 take precedence)} · CPC title

• A61P35/02

  specific for leukemia · CPC title

• C07K7/52 Primary

  with only normal peptide links in the ring · CPC title