Drive mechanism for a drug injection device comprising adhesive to block drive at end of device life to prevent reuse

Patent metadata

Field	Value
Publication number	US-9566394-B2
Application number	US-201314388556-A
Country	US
Kind code	B2
Filing date	Apr 2, 2013
Priority date	Apr 5, 2012
Publication date	Feb 14, 2017
Grant date	Feb 14, 2017

Abstract

A drive mechanism of a drug delivery device is presented having, a piston rod to operably engage with a piston of a cartridge containing a medicament, a first functional component and a second functional component whose position or orientation relative to each other is unambiguously correlated to a predefined axial position of the piston rod, wherein the first and/or the second functional component comprise at least one engaging portion to inseparably and to adhesively engage the first and the second functional component with each other for rendering the drive mechanism inoperable when the predefined axial position of the piston rod has been reached.

First claim

The invention claimed is:

1. A drive mechanism of a drug delivery device, comprising:
a piston rod to operably engage with a piston of a cartridge containing a medicament;
a first functional component; and
a second functional component,
where position or orientation of the first functional component and the second functional component relative to each other is unambiguously correlated to a predefined axial position of the piston rod,
wherein at least one of the first functional component and the second functional component comprises at least one engaging portion to inseparably and to adhesively engage the first functional component and the second functional component with each other for rendering the drive mechanism inoperable when the predefined axial position of the piston rod has been reached,
wherein the at least one engaging portion comprises a pressure sensitive adhesive, and
wherein the first functional component comprises the piston rod which is adapted to exert distally directed thrust to the piston of the cartridge, wherein the second functional component comprises an insert having a through opening through which the piston rod extends, wherein the piston rod comprises an outer thread engaged with an inner thread of the through opening, and wherein the at least one engaging portion is arranged at a proximal end of the piston rod.

2. The drive mechanism according to claim 1 , wherein the engaging portion comprises adhesive microspheres adapted to rupture when at least one of the engaging portion of the first functional component and the second functional component gets in mechanical contact with the other one of the first functional component and the second functional component.

3. The drive mechanism according to claim 1 , wherein the engaging portion comprises a lacquer containing rupturing adhesive microspheres.

4. A drug delivery device for dispensing a dose of a medicament, comprising:
xa housing,
a cartridge holder interconnected with the housing, and
a cartridge at least partially filled with the medicament and being arranged in the cartridge holder, and
a drive mechanism assembled inside the housing, the drive mechanism comprising:
a piston rod to operably engage with a piston of the cartridge containing the medicament;
a first functional component; and
a second functional component,
where position or orientation of the first functional component and the second functional component relative to each other is unambiguously correlated to a predefined axial position of the piston rod,
wherein at least one of the first functional component and the second functional component comprises at least one engaging portion to inseparably and to adhesively engage the first functional component and the second functional component with each other for rendering the drive mechanism inoperable when the predefined axial position of the piston rod has been reached,
wherein the at least one engaging portion comprises a pressure sensitive adhesive, and
wherein the first functional component comprises the piston rod which is adapted to exert distally directed thrust to the piston of the cartridge, wherein the second functional component comprises an insert having a through opening through which the piston rod extends, wherein the piston rod comprises an outer thread engaged with an inner thread of the through opening, and wherein the at least one engaging portion is arranged at a proximal end of the piston rod.

5. A drive mechanism of a drug delivery device, comprising:
a piston rod to operably engage with a piston of a cartridge containing a medicament;
a first functional component; and
a second functional component,
where position or orientation of the first functional component and the second functional component relative to each other is unambiguously correlated to a predefined axial position of the piston rod,
wherein at least one of the first functional component and the second functional component comprises at least one engaging portion to inseparably and to adhesively engage the first functional component and the second functional component with each other for rendering the drive mechanism inoperable when the predefined axial position of the piston rod has been reached,
wherein the at least one engaging portion comprises a pressure sensitive adhesive, and
wherein the first functional component comprises a nut threadedly engaged with the second functional component comprising a drive sleeve, wherein the nut is axially slidably engaged with a housing and rotationally locked to the housing and wherein the nut is further adapted to at least one of axially and tangentially abut against a flange portion of the drive sleeve when the predefined axial position of the piston rod has been reached, and wherein at least one of the nut and the flange portion comprise the at least one engaging portion to inseparably engage the nut and the flange portion when getting in mutual contact.

6. A drug delivery device for dispensing a dose of a medicament, comprising:
a housing,
a cartridge holder interconnected with the housing, and
a cartridge at least partially filled with the medicament and being arranged in the cartridge holder, and
a drive mechanism assembled inside the housing, the drive mechanism comprising:
a piston rod to operably engage with a piston of the cartridge containing the medicament;
a first functional component; and
a second functional component,
where position or orientation of the first functional component and the second functional component relative to each other is unambiguously correlated to a predefined axial position of the piston rod,
wherein at least one of the first functional component and the second functional component comprises at least one engaging portion to inseparably and to adhesively engage the first functional component and the second functional component with each other for rendering the drive mechanism inoperable when the predefined axial position of the piston rod has been reached,
wherein the at least one engaging portion comprises a pressure sensitive adhesive, and
wherein the first functional component comprises a nut threadedly engaged with the second functional component comprising a drive sleeve, wherein the nut is axially slidably engaged with a housing and rotationally locked to the housing and wherein the nut is further adapted to at least one of axially and tangentially abut against a flange portion of the drive sleeve when the predefined axial position of the piston rod has been reached, and wherein at least one of the nut and the flange portion comprise the at least one engaging portion to inseparably engage the nut and the flange portion when getting in mutual contact.

Assignees

• Sanofi Aventis Deutschland

Inventors

• Sendatzki Günther
• Jugl Michael

Classifications

• A61M5/24

  Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic {(ampoules or carpules A61J1/06)} · CPC title

• A61M2205/273

  preventing reuse, e.g. of disposables · CPC title

• A61M5/31551

  including axial movement of dose setting member · CPC title

• A61M5/50 Primary

  having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile {(retractable needles or needle protectors with means for preventing re-use A61M5/321)} · CPC title

• A61M5/502

  for blocking the piston · CPC title