Boron-containing small molecules
US-9353133-B2 · May 31, 2016 · US
Boron-containing small molecules
US9566290B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9566290-B2 |
| Application number | US-201615134286-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 20, 2016 |
| Priority date | Feb 16, 2005 |
| Publication date | Feb 14, 2017 |
| Grant date | Feb 14, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating a human having onychomycosis of a toenail caused by Trichophyton rubrum or Trichophyton mentagrophytes , the method comprising: topically administering to the toenail a pharmaceutical composition comprising an amount of 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt thereof, effective to inhibit an aminoacyl tRNA synthetase in the Trichophyton rubrum or Trichophyton mentagrophytes. 2. The method of claim 1 , wherein the pharmaceutical composition is in the form of a solution comprising 5% w/w of 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt thereof. 3. The method of claim 1 , wherein the pharmaceutical composition further comprises ethanol and propylene glycol. 4. The method of claim 1 , wherein the aminoacyl tRNA synthetase is leucyl tRNA synthetase. 5. The method of claim 4 , wherein the pharmaceutical composition is in the form of a solution comprising 5% w/w of 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt thereof. 6. The method of claim 5 , wherein the pharmaceutical composition further comprises ethanol and propylene glycol. 7. The method of claim 1 , wherein the administering of the pharmaceutical composition occurs once a day. 8. The method of claim 6 , wherein the administering of the pharmaceutical composition occurs once a day. 9. The method of claim 1 , wherein the method inhibits an aminoacyl tRNA synthetase in Trichophyton rubrum. 10. The method of claim 1 , wherein the method inhibits an aminoacyl tRNA synthetase in Trichophyton mentagrophytes. 11. The method of claim 6 , wherein the method inhibits leucyl tRNA synthetase in Trichophyton rubrum. 12. The method of claim 6 , wherein the method inhibits leucyl tRNA synthetase in Trichophyton mentagrophytes.
Assignees
Inventors
Classifications
Antimycotics · CPC title
- C07F5/025Primary
Boronic and borinic acid compounds · CPC title
Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047) · CPC title
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids · CPC title
Purine radicals · CPC title
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Frequently asked questions
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- What does patent US9566290B2 cover?
- This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by …
- Who is the assignee on this patent?
- Anacor Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification C07F5/025. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 14 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).