Antimicrobial solutions

Patent metadata

Field	Value
Publication number	US-9565857-B2
Application number	US-201113821546-A
Country	US
Kind code	B2
Filing date	Sep 9, 2011
Priority date	Sep 10, 2010
Publication date	Feb 14, 2017
Grant date	Feb 14, 2017

Abstract

The present invention provides antimicrobial solutions that in certain cases comprise a biguanide and a glycol ether and, in some cases, optionally also includes combinations of at least one an alcohol, at least one chelator, glycerol, deoxycholate, and/or at least one alkylpolyglucoside. In certain aspects the invention comprises a biguanide and deoxycholate or a combination of chelator, ethanol, and alkylpolyglucoside. Also provided are methods for rapidly killing and/or reducing bacteria, fungi, or virus from surfaces, for example, including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as medical equipment, pipelines etc.

First claim

What is claimed is:

1. An antimicrobial composition comprising (a) a biguanide selected from the group consisting of polyhexamethylene biguanide (PHMB), chlorhexidine, alexidine and hexamidine, (b) a dipropylene glycol n-butyl ether, and EDTA 4Na chelator, in respective amounts effective to eradicate a population of methicillin-resistant Staphylococcus aureus using a standard operating procedure (SOP) quantitative germicidal spray test.

2. The composition of claim 1 , wherein the composition further an alkylpolyglucoside.

3. The composition of claim 1 , wherein the biguanide is chlorhexidine.

4. The composition of claim 1 , further comprising an effective amount of deoxycholate.

5. The composition of claim 2 , wherein the alkylpolyglucoside is selected from the group consisting of capryl glucoside, decyl glucoside, coco-glucoside, and lauryl glucoside.

6. A method for eradicating drug resistant bacteria on a surface comprising contacting the surface with the composition of claim 1 for at least one minute.

7. The method of claim 6 , wherein the composition further comprises an alkylpolyglucoside.

8. The method of claim 6 , wherein the biguanide is chlorhexidine.

9. The method of claim 6 , further comprising an effective amount of deoxycholate.

10. The method of claim 7 , wherein the alkylpolyglucoside is selected from the group consisting of capryl glucoside, decyl glucoside, coco-glucoside, and lauryl glucoside.

11. The method of claim 6 , wherein the drug resistant bacteria are selected from the group consisting of MRSA, vancomycin resistant enterobacter (“VRE”) and multi-drug resistant P. aeruginosa and Actinetobacter.

12. The method of claim 11 , wherein the drug resistant bacteria are MRSA.

13. A kit for disinfecting a surface, wherein the kit comprises the composition of claim 1 .

14. The kit of claim 13 , wherein the biguanide and the dipropylene glycol n-butyl ether are contained in separate containers.

15. A syringe, comprising a unit dose of a pharmacologically effective amount of a solution comprising the composition of claim 1 .

16. The antimicrobial composition of claim 1 , wherein the biguanide is PHMB.

17. The method of claim 6 , wherein the biguanide is PHMB.

18. The composition of claim 1 , wherein the composition does not include at least one alcohol.

19. The method of claim 6 , wherein the composition does not include at least one alcohol.

20. The kit of claim 13 , wherein the composition does not include at least one alcohol.

21. The syringe of claim 15 , wherein the composition does not include at least one alcohol.

Assignees

• Raad Issam
• Abiaad George
• Univ Texas

Inventors

• Raad Issam
• Abiaad George

Classifications

• A61L2103/15

  Laboratory, medical or dentistry appliances, e.g. catheters or sharps · CPC title

• A61K31/715

  Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters · CPC title

• A61L2/186

  Peroxide solutions · CPC title

• A61K31/155

  Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2) · CPC title

• A61L29/16

  Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} · CPC title