Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field

Patent metadata

Field	Value
Publication number	US-9561202-B2
Application number	US-201514671579-A
Country	US
Kind code	B2
Filing date	Mar 27, 2015
Priority date	Jul 22, 2005
Publication date	Feb 7, 2017
Grant date	Feb 7, 2017

Abstract

The present invention relates to compounds comprising the general formula (I), in which R 1 and R 2 , which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising —H, —OH, —COOH, —OR 3 , —CH(OR 3 )COOH, in which R 3 is selected from H, phenyl, benzyl, —CF 3 or —CF 2 CF 3 , vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.

First claim

The invention claimed is:

1. A method of treating a colon cancer, comprising administering to a mammal in need thereof a compound represented by the general formula (I)

in which
R 1 and R 2 , which may be identical or different, are selected from the group consisting of —H or a linear or branched alkyl group having from 1 to 6 carbon atoms;
Y is selected from the group consisting of —H, —OH, —OR 3 , or —COOH wherein R 3 is selected from the group consisting of phenyl, benzyl, —CF 3 , —CF 2 CF 3 , vinyl, allyl, and a linear or branched alkyl group having from 1 to 6 carbon atoms;
Z is selected from the group consisting of —OR 3 , and —CH(OR 3 )COOH, in which R 3 is selected from the group consisting of H, phenyl, benzyl, —CF 3 or —CF 2 CF 3 , vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms; or salts thereof.

2. The method of claim 1 , wherein the mammal is a human.

3. The method of claim 1 , wherein Y is H.

4. The method of claim 1 , wherein Z is —CH(OR 3 )COOH, wherein R 3 is selected from the group consisting of —CH 3 or —CH 2 CH 3 .

5. The method of claim 1 , wherein the compound is selected from the group consisting of:

6. The method of claim 5 , wherein the compound is

7. The method of claim 1 , wherein the compound is (R)-2-methoxy-3-(4′-aminophenyl)propionic acid.

8. The method of claim 1 , wherein the compound is (S)-2-methoxy-3-(4′-aminophenyl)propionic acid.

9. The method of claim 1 , wherein the compound is selected from the group consisting of: ±-2-hydroxy-2-(3′-aminophenyl)acetic acid, ±-2-hydroxy-2-(4′-aminophenyl)acetic acid, ±-2-hydroxy-3-(4′-aminophenyl)propionic acid, ±-2-methoxy-3-(3′-aminophenyl)propionic acid and ±-2-methoxy-3-(4′-aminophenyl)propionic acid.

Assignees

• Nogra Pharma Ltd

Inventors

• Naccari Giancarlo
• Baroni Sergio

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P35/04

  specific for metastasis · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title