Neisseria meningitidis compositions and methods thereof
US-8986710-B2 · Mar 24, 2015 · US
Stable formulations of Neisseria meningitidis rLP2086 antigens
US9556240B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9556240-B2 |
| Application number | US-201113814285-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 22, 2011 |
| Priority date | Aug 23, 2010 |
| Publication date | Jan 31, 2017 |
| Grant date | Jan 31, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention relates to stable formulations of Neisseria meningitis rLP2086 Subfamily B Antigens in immunogenic compositions. The present invention also relates to methods of preserving the conformation of Neisseria meningitis rLP2086 Antigens and methods for determining the potency of Neisseria meningitis rLP2086 antigens.
First claim
Opening claim text (preview).
What is claimed is: 1. An immunogenic composition consisting essentially of 120 μg/mL of a purified lipidated Neisseria meningitidis serogroup B LP2086 (fHBP) Subfamily B polypeptide; Polysorbate 80, wherein the molar ratio of the Polysorbate 80 to the polypeptide is 2.8:1; 0.5 mg/mL aluminum as aluminum phosphate; 10 mM histidine at a pH of 6.0; and 150 mM sodium chloride. 2. An immunogenic composition consisting essentially of 120 μg/mL of a purified lipidated Neisseria meningitidis serogroup B LP2086 (fHBP) Subfamily B polypeptide; 120 μg/mL of a purified lipidated Neisseria meningitidis serogroup B LP2086 (fHBP) Subfamily A polypeptide; Polysorbate 80, wherein the molar ratio of the Polysorbate 80 to the polypeptide is 2.8:1; 0.5 mg/mL aluminum as aluminum phosphate; 10 mM histidine at a pH of 6.0; and 150 mM sodium chloride. 3. An immunogenic composition consisting essentially of 120 μg/mL of a purified lipidated Neisseria meningitidis serogroup B LP2086 (fHBP) Subfamily B polypeptide; Polysorbate 80, wherein the molar ratio of the Polysorbate 80 to the polypeptide is 2.8:1; 0.5 mg/mL aluminum as aluminum phosphate; 5 mM succinate at a pH 6.0; and 150 mM sodium chloride. 4. An immunogenic composition consisting essentially of 120 μg/mL of a purified lipidated Neisseria meningitidis serogroup B LP2086 (fHBP) subfamily B polypeptide; 120 μg/mL of a purified lipidated Neisseria meningitidis serogroup B LP2086 (fHBP) Subfamily A polypeptide; Polysorbate 80, wherein the molar ratio of the Polysorbate 80 to the polypeptide is 2.8:1; 0.5 mg/mL aluminum as aluminum phosphate; 5 mM succinate at a pH of 6.0; and 150 mM sodium chloride.
Assignees
Inventors
Classifications
Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers · CPC title
- A61K39/095Primary
Neisseria · CPC title
Bacteria · CPC title
Inorganic adjuvants · CPC title
- C07K14/22Primary
from Neisseriaceae (F) · CPC title
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Frequently asked questions
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- What does patent US9556240B2 cover?
- The present invention relates to stable formulations of Neisseria meningitis rLP2086 Subfamily B Antigens in immunogenic compositions. The present invention also relates to methods of preserving the conformation of Neisseria meningitis rLP2086 Antigens and methods for determining the potency of Neisseria meningitis rLP2086 antigens.
- Who is the assignee on this patent?
- Khandke Lakshmi, Arumugham Rasappa, Loun Bounthon, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/095. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 31 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).