Assessment of cardiac wall motion using impedance measurements

Patent metadata

Field	Value
Publication number	US-9555249-B2
Application number	US-55120109-A
Country	US
Kind code	B2
Filing date	Aug 31, 2009
Priority date	Aug 31, 2009
Publication date	Jan 31, 2017
Grant date	Jan 31, 2017

Abstract

In accordance with the techniques for heart monitoring described in this disclosure, an implantable medical device (IMD) may assess cardiac wall motion using impedance measurements through cardiac leads. As an example, the IMD may calculate an amount or rate of change in impedance due to the motion of a wall of the heart during at least a portion of one cardiac cycle, e.g., systole, in order to assess the strength of systolic contraction.

First claim

The invention claimed is:

1. A method comprising:
measuring an impedance of an electrical path that includes a portion of a heart wall a plurality of times during at least one portion of a cardiac cycle, the electrical path comprising a first electrode engaged to or within a wall of a chamber of a heart and a second electrode, wherein the second electrode is an extra-cardiac electrode that is disconnected from the heart; and
calculating a value indicative of heart wall motion during the portion of the cardiac cycle based on the impedance measurements.

2. The method of claim 1 , wherein the value comprises a change in impedance during the at least one portion of the cardiac cycle.

3. The method of claim 1 , wherein the value comprises a rate of change in impedance during the at least one portion of the cardiac cycle.

4. The method of claim 1 , wherein the at least one portion of the cardiac cycle is a systolic period.

5. The method of claim 1 , further comprising comparing the value to a previously stored value.

6. The method of claim 5 , wherein the previously stored value is representative of a trend of values indicative of heart wall motion over time.

7. The method of claim 5 , further comprising:
determining a change in cardiac contractility based upon the comparison.

8. The method of claim 5 , further comprising:
assessing a hemodynamic significance of ventricular tachyarrhythmia based upon the comparison; and
determining whether to provide electrical stimulation therapy or adjust electrical stimulation therapy based upon the assessment.

9. The method of claim 5 , further comprising:
adjusting a timing interval for cardiac resynchronization therapy based upon the comparison.

10. The method of claim 1 , further comprising:
filtering the impedance measurements.

11. The method of claim 5 , further comprising:
providing an alert based upon the comparison.

12. The method of claim 1 , wherein the second electrode comprises one of a housing electrode of an implantable medical device or a superior vena cava coil electrode.

13. A system for assessing cardiac wall motion, the system comprising:
an impedance measurement module that measures an impedance of an electrical path that includes a portion of a heart wall a plurality of times during at least one portion of a cardiac cycle, the electrical path comprising a first electrode engaged to or within a wall of a chamber of a heart and a second electrode wherein the second electrode is an extra-cardiac electrode that is disconnected from the heart; and
a processor that is configured to:
calculate a value indicative of heart wall motion during the portion of the cardiac cycle based on the impedance measurements.

14. The system of claim 13 , wherein the value comprises a change in impedance during the at least one portion of the cardiac cycle.

15. The system of claim 13 , wherein the value comprises a rate of change in impedance during the at least one portion of the cardiac cycle.

16. The system of claim 13 , wherein the at least one portion of the cardiac cycle is a systolic period.

17. The system of claim 13 , wherein the processor is further configured to:
compare the value to a previously stored value.

18. The system of claim 17 , wherein the previously stored value is representative of a trend of values indicative of heart wall motion over time.

19. The system of claim 17 , wherein the processor is further configured to determine a change in cardiac contractility based upon the comparison.

20. The system of claim 17 , wherein the processor is further configured to:
assess a hemodynamic significance of ventricular tachyarrhythmia based upon the comparison; and
determine whether to provide electrical stimulation therapy or adjust electrical stimulation therapy based upon the assessment.

21. The system of claim 17 , wherein the processor is further configured to:
automatically adjust a timing cycle of an implantable device based on the comparison.

22. The system of claim 13 , further comprising:
a filter that filters the impedance measurements.

23. The system of claim 13 , wherein the processor is further configured to provide an alert based upon the comparison.

24. The system of claim 13 , wherein the second electrode comprises one of a housing electrode of an implantable medical device or a superior vena cava coil electrode.

25. A device for assessing cardiac wall motion, the device comprising:
an impedance measurement module that measures an impedance of an electrical path that includes a portion of a heart wall a plurality of times during at least one portion of a cardiac cycle, the electrical path comprising a first electrode engaged to or within a wall of a chamber of a heart and a second electrode wherein the second electrode is an extra-cardiac electrode that is disconnected from the heart; and
a processor that is configured to:
calculate a value indicative of heart wall motion during the portion of the cardiac cycle based on the impedance measurements.

26. The device of claim 25 , wherein the value comprises a change in impedance during the at least one portion of the cardiac cycle.

27. The device of claim 25 , wherein the value comprises a rate of change in impedance during the at least one portion of the cardiac cycle.

28. The device of claim 25 , wherein the at least one portion of the cardiac cycle is a systolic period.

29. The device of claim 25 , wherein the processor is further configured to:
compare the value to a previously stored value.

30. The device of claim 29 , wherein the previously stored value is representative of a trend of values indicative of heart wall motion over time.

31. The device of claim 29 , wherein the processor is further configured to determine a change in cardiac contractility based upon the comparison.

32. The device of claim 29 , wherein the processor is further configured to:
assess a hemodynamic significance of ventricular tachyarrhythmia based upon the comparison; and
determine whether to provide electrical stimulation therapy or adjust electrical stimulation therapy based upon the assessment.

33. The device of claim 29 , wherein the processor is further configured to:
automatically adjust a timing cycle of an implantable device based on the comparison.

34. The device of claim 25 , further comprising:
a filter that filters the impedance measurements.

35. The device of claim 25 , wherein the processor is further configured to provide an alert based upon the comparison.

36. The device of claim 25 , wherein the second electrode comprises one of a housing electrode of an implantable medical device or a superior vena cava coil electrode.

37. A non-transitory computer-readable storage medium comprising instructions encoded on the computer-readable medium that, upon execution, cause a processor within an implantable medical device to:
measure an impedance of an electrical path that includes a portion of a heart wall a plurality of times during at least one portion of a cardiac cycle, the electrical path comprising a first electrode engaged to or within a wall of a chamber of a heart and a second electrode, wherein the second electrode is an extra-ca

Assignees

• Chow Theodore
• Medtronic Inc

Inventors

• Chow Theodore

Classifications

• A61B5/6846

  specially adapted to be brought in contact with an internal body part, i.e. invasive · CPC title

• A61B5/7275

  Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor · CPC title

• A61N1/36521

  the parameter being derived from measurement of an electrical impedance · CPC title

• A61N1/3622 Primary

  comprising two or more electrodes co-operating with different heart regions · CPC title

• A61N1/37247

  User interfaces, e.g. input or presentation means · CPC title