Inorganically surface-modified polymers and methods for making and using them

Patent metadata

Field	Value
Publication number	US-9555159-B2
Application number	US-201514685487-A
Country	US
Kind code	B2
Filing date	Apr 13, 2015
Priority date	Jul 6, 2010
Publication date	Jan 31, 2017
Grant date	Jan 31, 2017

Abstract

In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.

First claim

What is claimed:

1. A product of manufacture comprising:
(a) a thermoplastic polymer; and
(b) a biocompatible surface layer deposited on at least a portion of a surface of the thermoplastic polymer, wherein the biocompatible surface layer comprises a plurality of nanotubular structures and each nanotubular structure of the plurality of nanotubular structures has a diameter of approximately 5 to 1000 nanometers (nm),
wherein each nanotubular structure of the plurality of nanotubular structures has a diameter of approximately 8 nanometers (nm).

2. The product of manufacture of claim 1 , wherein at least approximately 50% of the biocompatible surface layer is covered by the plurality of nanotubular structures.

3. The product of manufacture of claim 1 , wherein any of the biocompatible surface layer and the plurality of nanotubular structures comprise a material selected from the group consisting of:
(i) a material selected from the group consisting of a Ti, a Zr, a Hf, a Nb, a Ta, a Mo and a W metal;
(ii) a material selected from the group consisting of an oxide of a Ti, a Zr, a Hf, a Nb, a Ta, a Mo and a W metal;
(iii) a material selected from the group consisting of an alloy of a Ti, a Zr, a Hf, a Nb, a Ta, a Mo and a W metal;
(iv) a material selected from the group consisting of a Si, a Si oxide, an Al, an Al oxide, a carbon, a diamond, a noble metal, an Au, an Ag, a Pt, an Ag oxide, and a Pt alloy,
(v) a plastic material,
(vi) a composite metal,
(vii) a ceramic,
(vii) a polymer, and
(viii) a combination thereof.

4. The product of manufacture of claim 1 :
further comprising any of at least one of a bone cell, a liver cell, a kidney cell, a blood vessel cell, a skin cell, a periodontal cell, a periodontal tissue cell, a stem cell, an organ cell, a fully differentiated osteoblast cell, a partially differentiated osteoblast cell, a mesenchymal stem cell (MSC), a human mesenchymal stem cell (hMSC), an embryonic stem cell, an adult stem cell, endothelial cells, adipocytes, fibroblastic cells, Kupffer cells, odontoblasts, dentinoblasts, cementoblasts, enameloblasts, odontogenic ectomesenchymal tissue, osteoblasts, osteoclasts, fibroblasts, a cell involved in odontogenesis or bone formation, a human cell, an animal cell, and a combination thereof.

5. The product of manufacture of claim 1 , further comprising any of a hydroxyapatite, a bio-degradable polymer, a bio-compatible cement, a bio-inert bone cement, a biological agent, a therapeutic composition, an osteogenic inducing agent, a growth factor, a collagen, a nucleic acid, an antibiotic, a hormone, a drug, a magnetic particle, a metallic particle, a ceramic particle, a polymer particle, a drug delivery particle, and a combination thereof.

6. The product of manufacture of claim 1 , wherein the plurality of nanotubular structures:
are in the form of any of nanowires, nano-lines, nano-grooves, nanotubes, nanopores, and a combination thereof.

7. The product of manufacture of claim 1 , wherein the plurality of nanotubular structures and spacing between adjacent nanotubular structures act as a nanodepot that stores any of a metal, an oxide, a hydroxyapatite, a bio-degradable polymer, a bio-compatible bone cement, a bio-inert bone cement, a cell, a stem cell, an osteogenic inducing agent, a biological agent, a therapeutic composition, a growth factor, a collagen, a nucleic acid, an antibiotic, a hormone, a drug, a magnetic particle, a metallic particle, a ceramic particle, a polymer particle, a drug delivery particle, and a combination thereof.

8. A device comprising a product of manufacture of claim 1 , and optionally the device is a delivery device.

9. An implant comprising a product of manufacture of claim 1 , and optionally the implant is any of a medical implant, an orthopedic implant, a joint implant, a joint replacement, a dental implant, a tooth implant, a knee implant, a hip implant, a shoulder implant, a joint implant, a spinal implant, a joint replacement, a dental replacement, a tooth replacement, a knee replacement, a hip replacement, and a shoulder replacement.

10. A product of manufacture of claim 1 , fabricated for any of in vivo hard tissue applications, in vivo soft tissue applications, and in vivo hard tissue and soft tissue applications.

11. The product of manufacture of claim 10 , wherein the in vivo soft tissue applications include any of: use with a catheter, use with an implantable device that promotes cell growth, and, use with a biosensor that reduces a fibrotic capsule which blocks any of an electrical and a chemical signal.

12. The product of manufacture of claim 10 , wherein the in vivo hard tissue applications include any of:
an orthopedic implant,
an orthopedic replacement,
a joint implant,
a joint replacement,
a hip stem,
a knee implant,
a shoulder replacement,
a dental implant,
a craniofacial implant;
a spine application,
a cervical instrumentation,
a thoracic instrumentation,
a lumbar spinal instrumentation,
an interbody vertebral cage,
a pedicle screw,
a bone substitute material,
a bone void filler,
a bone graft material, and
a combination thereof.

13. The product of manufacture of claim 10 , wherein the in vivo hard tissue and soft tissue applications include any of:
a trauma application,
a fixation device,
an internal fixation device,
an external fixation device,
a fixation device,
an internal fixation device,
an external fixation device, and
a rod.

14. A product of manufacture of claim 1 , fabricated for in vitro applications.

15. The product of manufacture of claim 1 , wherein the thermoplastic polymer is any of a PolyEther EtherKetone (PEEK), a PolyEtherKetoneKetone (PEKK), a PolyEther EtherKetone (PEEK), an ultra-high-molecular-weight polyethylene (UHMWPE), a combination thereof, and an equivalent material thereof.

16. The product of manufacture of claim 1 , wherein the plurality of nanotubular structures comprise any of a metal, a metal alloy, a stainless steel, and a ceramic, and optionally the metal and the metal alloy comprise any of a Ti metal, a Zr metal, a Hf metal, a Nb metal, a Ta metal, a Mo metal, a W metal, a Ti alloy, a Zr alloy, a Hf alloy, a Nb alloy, a Ta alloy, a Mo alloy, a W alloy, a Ti oxide, a Zr oxide, a Hf oxide, a Nb oxide, a Ta oxide, a Mo oxide, a W oxide, and a nitride.

17. The product of manufacture of claim 1 , wherein the plurality of nanotubular structures are any of straight, curved, and bent, or are arranged as any of an array and a three-dimensional network scaffold.

18. The product of manufacture of claim 1 , wherein the thermoplastic polymer comprises a PolyEther EtherKetone (PEEK) and the biocompatible surface layer comprises a layer of titanium (Ti), optionally sputtered on all or part of a surface of the thermoplastic polymer.

19. The product of manufacture of claim 1 , wherein a spacing between each nanotubular structure of the plurality of nanotubular structures is any of approximately 70 to 200 nanometers (nm), 60 to 150 nm, 80 to 120 nm, 60 nm, 65 nm, 70 nm, 75 nm, 80 nm, 85 nm, 90 nm, 95 nm, 100 nm, 105 nm, 110 nm, 115 nm, 120 nm, 125 nm, 130 nm, 135 nm, 145 nm, 150 nm, 155 nm, 165 nm, 170 nm, 175 nm, 180 nm, 185 nm, 190 nm, and 200 nm or more, and optionally each nanotubular structure of the plurality of nanotubular structures is approximately 0.1 to 3 micrometer in height.

20. The product of manufacture of claim 1 , wherein each nanotubular structure of the plurality of nanotubular structures has an approximately 0.1 to 3 micromete

Assignees

• Univ California

Inventors

• Jin Sungho
• Smith Garrett
• Choi Chulmin

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• B32B2307/732

  Dimensional properties · CPC title

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title

• A61K35/545

  Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells · CPC title

• B32B27/32

  comprising polyolefins {(comprising vinyl (co)polymers or acrylic (co)polymers B32B27/30)} · CPC title