System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US9554857B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9554857-B2 |
| Application number | US-201213420340-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 14, 2012 |
| Priority date | Sep 14, 2009 |
| Publication date | Jan 31, 2017 |
| Grant date | Jan 31, 2017 |
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Exemplary embodiments of apparatus, system, computer-accessible medium, procedure and method are provided which can be used for providing laser steering and focusing for, e.g., incision, excision and/or ablation of tissue in minimally-invasive surgery. For example, the exemplary apparatus can include at least one optical element which can be configured to refract and/or diffract light provided in a structure which can be configured to be inserted into a body, where at least one of the optical element(s) is structured to receive the light at a first angle and generate a refracted and/or diffracted light at a second angle which can be different from the first angle relative to an optical axis. For example, an actuating arrangement can be provided, which can be configured to control the optical element(s), can be provided and situated at least partially within the at least one structure.
Opening claim text (preview).
What is claimed is: 1. An endoscopic laser scalpel system, comprising: a surgical laser source providing laser light for at least one of incision, excision, and ablation of tissue in minimally invasive surgery; a laryngoscope or endoscope having a distal end to be inserted into a body cavity to deliver the laser light to a target tissue therein; and an endoscopic head mounted on the distal end of the laryngoscope or endoscope, the endoscopic head comprising: an expansion lens positioned to expand the laser light from the laser source; a collimating lens positioned to collimate the laser light from the expansion lens; a focusing lens interfacing the endoscopic head to the body cavity; and at least two rotatable optical elements positioned between the collimating lens and the focusing lens, each of which comprises an optical wedge or prism configured to refract light or a diffraction grating configured to diffract light, wherein the rotatable optical elements and the lenses are aligned with their centers on a common optical axis, and each of the optical elements is configured to rotate about the optical axis, wherein the rotatable optical elements are each structured to receive incident laser light at a first elevation angle with respect to the optical axis, and generate refracted or diffracted laser light at a second elevation angle which is different from the first elevation angle with respect to the optical axis, and wherein the refracted or diffracted laser light is generated with a second rotation angle around the optical axis that is dependent on a first rotation angle of the respective rotatable optical element around the optical axis. 2. The endoscopic laser scalpel system according to claim 1 , wherein the laser source comprises an optical waveguide. 3. The endoscopic laser scalpel system according to claim 1 , wherein the at least two rotatable optical elements comprise a Risley prism pair. 4. The endoscopic laser scalpel system according to claim 1 , wherein the diffraction grating (a) has a variable pitch and comprises an acousto-optical device or a liquid crystal device, or (b) has a fixed pitch. 5. The endoscopic laser scalpel system according to claim 2 , wherein the optical wave guide is a hollow core or photonic bandgap optical fiber. 6. The endoscopic laser scalpel system according to claim 1 , further comprising at least two actuating arrangements each configured to rotate the respective optical elements around the optical axis to change the second rotation angle of the refracted or diffracted laser light, each actuating arrangement comprising a mounting ring to which the respective optical element is mounted, a magnetic ring attached to the mounting ring, at least one sensor to measure the position of the magnetic ring, and a motor to rotate the mounting ring. 7. The endoscopic laser scalpel system according to claim 4 , wherein the diffraction grating of fixed pitch comprises a holographic transmission grating or a blazed grating.
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