Specimen information acquisition apparatus and method therefor

Patent metadata

Field	Value
Publication number	US-9554709-B2
Application number	US-201214112228-A
Country	US
Kind code	B2
Filing date	Apr 5, 2012
Priority date	Apr 18, 2011
Publication date	Jan 31, 2017
Grant date	Jan 31, 2017

Abstract

There is provided a specimen information acquisition apparatus that can obtain an image in which an influence of a local fluence distribution in a specimen is reduced. A signal processing apparatus includes a region extraction unit and an optical constant estimation unit. The region extraction unit extracts two or more regions that have a known absorption coefficient, from an optical characteristic value distribution of the specimen. The optical constant estimation unit estimates an optical constant of a background of the specimen by using optical characteristic values of the two or more regions extracted by the region extraction unit and a local fluence distribution obtained from an optical constant which is set in advance for the specimen background.

First claim

The invention claimed is:

1. An apparatus comprising:
a light source configured to irradiate a specimen with light;
a detector configured to output a signal by detecting an acoustic wave that is produced by irradiating the specimen with the light; and
a memory in communication with a processor, the memory storing instructions that, when executed by the processor, causes the processor to:
calculate, by using the signal, a first optical characteristic value distribution in the specimen, the first optical characteristic value distribution being an initial sound pressure distribution or an optical energy absorption density distribution which represents the product of an absorption coefficient distribution and a local fluence distribution;
determine, by using the first optical characteristic value distribution, two or more regions of a vessel in the specimen;
determine from the first optical characteristic value distribution, the initial sound pressure distribution or the optical energy absorption density distribution of the determined two or more regions of the vessel;
calculate, by using the initial sound pressure distribution or the optical energy absorption density distribution of the determined two or more regions of the vessel, an average optical constant of a background region which surrounds the two or more regions of the vessel;
calculate, by using the calculated average optical constant of the background region, the local fluence distribution in the specimen; and
calculate, by dividing the first optical characteristic value distribution by the local fluence distribution, a second optical characteristic value distribution in which the first optical characteristic value distribution is corrected.

2. The apparatus according to claim 1 , wherein the processor is configured to calculate, by using the first optical characteristic value distribution, an initial sound pressure value distribution or an optical energy absorption density value distribution in the specimen.

3. The apparatus according to claim 1 , wherein the processor is configured to calculate, as the average optical constant, any of an average absorption coefficient, an average scattering coefficient, an average anisotropic parameter, an average reduced scattering coefficient, and an effective attenuation coefficient.

4. The apparatus according to claim 1 , wherein the processor is configured to determine, by using the first optical characteristic value distribution, the two or more regions of the vessel having a known absorption coefficient, and
wherein, when the average optical constant is a variable, the processor is configure to calculate the average optical constant of the specimen by minimizing a difference between the first optical characteristic values and a product of a light quantity obtained based on the average optical constant and a known absorption coefficient for the determined two or more regions.

5. The apparatus according to claim 1 , wherein
the processor is configured to calculate a local fluence distribution in the specimen by using the average optical constant, and to calculate the second optical characteristic value distribution on the basis of the first optical characteristic value distribution and the local fluence distribution.

6. The apparatus according to claim 1 , wherein the processor is configured to determine the two or more regions of the vessel having a known absorption coefficient in the specimen.

7. The apparatus according to claim 1 , wherein the processor is configured to calculate, as the average optical constant, an average absorption coefficient and an average reduced scattering coefficient.

8. The apparatus according to claim 1 , wherein the processor is configured to determine, by using the first optical characteristic value distribution, the two or more regions of the vessel having a known absorption coefficient, and
wherein the processor is configured to calculate the average optical constant that satisfies a relational equation of optical characteristic values of the determined two or more regions in the first optical characteristic value distribution, local fluence values, obtained based on the average optical constant of the determined the two or more regions, and the known absorption coefficient of the determined two or more regions.

9. The apparatus according to claim 1 , wherein the processor is configured to determine, by using the first optical characteristic value distribution, the two or more regions of the vessel having a known absorption coefficient, and
wherein, when the average optical constant is a variable, the processor is configured to calculate the average optical constant, using an optimization method so that a relation between optical characteristic values in the first optical characteristic value distribution and a product of local fluence value obtained based on the average optical constant and the known absorption coefficient is satisfied in the determined two or more regions.

10. The apparatus according to claim 1 , wherein the processor is configured to determine, by using the first optical characteristic value distribution, the two or more regions which are portions of a same vessel.

11. The apparatus according to claim 1 , wherein the processor is configured to determine, by using the first optical characteristic value distribution, the two or more regions of the vessel having a same absorption coefficient.

12. The apparatus according to claim 1 , wherein the light source is configured to irradiate the specimen with light having a wavelength of 500-900 nm.

13. The apparatus according to claim 1 , wherein the processor is configured to determine, by using a region specified based on a designation of an operator for the first optical characteristic value distribution, the two or more regions of the vessel in the specimen.

14. The apparatus according to claim 1 ,
wherein the processor is configured to calculate, as the average optical constant, an average absorption coefficient and an average reduced scattering coefficient,
wherein the processor is configured to calculate, by using the average absorption coefficient and the average reduced scattering coefficient, information on a local fluence value distribution in the specimen, and
wherein the processor is configured to calculate, by using the first optical characteristic value distribution and the local fluence value distribution, an absorption coefficient distribution in the specimen.

15. The apparatus according to claim 1 ,
wherein the processor is configured to calculate, as the average optical constant, an effective attenuation coefficient,
wherein the processor is configured to calculate, by using the effective attenuation coefficient, a local fluence value distribution in the specimen, and
wherein the processor is configured to calculate, by using the first optical characteristic value distribution and the local fluence value distribution, an absorption coefficient distribution in the specimen.

16. A method used for an apparatus which includes a memory in communication with a processor, the memory storing instructions that, when executed by the processor, causes the processor to perform the method comprising the steps of:
calculating a first optical characteristic value distribution in a specimen on the basis of a signal obtained through detection of an acoustic wave that is produced by irradiating the specimen with light, the first optical characteristic value distribution being an initial sound pressure distribution or an optical energy absorption density distribution which represents the p

Assignees

• Fukutani Kazuhiko
• Canon Kk

Inventors

• Fukutani Kazuhiko

Classifications

• A61B5/7485

  Automatic selection of region of interest · CPC title

• G01N29/2418

  using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics (photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046) · CPC title

• A61B5/0095 Primary

  by applying light and detecting acoustic waves, i.e. photoacoustic measurements · CPC title

• A61B5/02007

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• G01N21/1702

  with opto-acoustic detection, e.g. for gases or analysing solids · CPC title