Sensing zone for spatially relevant electrical information

Patent metadata

Field	Value
Publication number	US-9549683-B2
Application number	US-201213650678-A
Country	US
Kind code	B2
Filing date	Oct 12, 2012
Priority date	Oct 12, 2011
Publication date	Jan 24, 2017
Grant date	Jan 24, 2017

Abstract

Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

First claim

What is claimed is:

1. A computer-implemented method comprising:
identifying a region of interest for an anatomical structure located within a patient's body; and
defining a spatial zone as a subset of a plurality of electrodes on a body surface of the patient's body corresponding to the region of interest by correlating electrical activity at the region of interest with body surface electric activity measured by the subset of the plurality of electrodes, wherein the body surface electrical activity in the spatial zone provides a surrogate estimate for electrical activity of the region of interest.

2. The method of claim 1 , further comprising:
acquiring electrical signals from the zone or outside the zone; and
converting the acquired electrical signals to corresponding reconstructed electrical signals for the region of interest via an inverse reconstruction based on an inverse matrix of influence coefficients.

3. The method of claim 2 , further comprising generating a graphical map based on the corresponding reconstructed electrical signals for the region of interest.

4. The method of claim 1 , wherein the region of interest comprises a selected region of a heart in the patient's body, the method further comprising:
acquiring body surface electrical potentials from at least the zone; and
analyzing the acquired body surface electrical potentials for the zone to provide electrical information that is spatially relevant for the selected region of the heart.

5. The method of claim 4 , further comprising generating a graphical map for the selected region of the heart based on the acquired body surface electrical potentials to represent the electrical information that is spatially relevant for the selected region of the heart.

6. The method of claim 4 , wherein the analyzing further comprises computing an activation time for each of a plurality of points residing in the zone based on the acquired body surface electrical potentials, which correspond to the activation time for each of a plurality of nodes in the region of interest.

7. The method of claim 1 , wherein the region of interest comprises a region of a heart in the patient's body, the method further comprising:
acquiring electrical potentials for each of a plurality of different predetermined zones on the body surface from a plurality of electrodes, wherein the plurality of different predetermined zones each comprises a subset of the plurality of electrodes; and
analyzing the acquired electrical potentials for each of the plurality of different zones to compute a plurality of surrogate estimates of electrical activity for each of a plurality of corresponding spatial regions of interest of the heart.

8. The method of claim 7 , wherein the plurality of surrogate estimates provide an indication of at least one of an activation time or a recovery time for each of the plurality of corresponding spatial regions of the heart.

9. The method of claim 8 , further comprising:
identifying a proper subset of body surface channels that contribute the most to each and every location of the heart; and
constructing a transformation matrix for the identified proper subset of body surface channels.

10. The method of claim 7 , wherein the plurality of surrogate estimates provide an indication of relative synchrony among the plurality of corresponding spatial regions of the heart.

11. The method of claim 7 , wherein the acquiring further comprises:
acquiring a first set of body surface electrical data by measuring electrical potentials for each of the plurality of different predetermined zones on the body surface during a first time interval; and
acquiring a second set of body surface electrical data by measuring electrical potentials for each of the plurality of different predetermined zones on the body surface during another time interval;
the method further comprising:
computing a first surrogate estimate of electrical activity for each of a plurality of corresponding spatial regions of interest of the heart based on the first set of body surface electrical data; and
computing a second surrogate estimate of electrical activity for each of a plurality of corresponding spatial regions of interest of the heart based on the second set of body surface electrical data.

12. The method of claim 11 , further comprising at least one of spatially and temporally comparing the first surrogate estimate of electrical activity and the second surrogate estimate of electrical activity.

13. The method of claim 11 , wherein the first time interval is before applying a therapy to a given spatial region of the heart, the another time interval being one of during or after the therapy is applied to the given spatial region of the heart.

14. The method of claim 13 , wherein the therapy comprises at least one of an electrical stimulation therapy, a radio frequency therapy and a thermal therapy.

15. The method of claim 11 , further comprising generating a graphical map based on the first surrogate estimate of electrical activity and generating another graphical map based on the second surrogate estimate of electrical activity.

16. The method of claim 7 , wherein the acquiring further comprises:
acquiring a first set of body surface electrical data by measuring electrical potentials for at least one of the plurality of different predetermined zones on the body surface during a first time interval; and
acquiring a second set of body surface electrical data by measuring electrical potentials for the same at least one of the plurality of different predetermined zones on the body surface during another time interval;
the method further comprising:
computing a first surrogate estimate of electrical activity for each of a plurality of corresponding spatial regions of interest of the heart based on the first set of body surface electrical data; and
computing a second surrogate estimate of electrical activity for each of a plurality of corresponding spatial regions of interest of the heart based on the second set of body surface electrical data.

17. The method of claim 16 , further comprising comparing the first surrogate estimate of electrical activity and the second surrogate estimate of electrical activity.

18. The method of claim 16 , wherein the first time interval is before applying a therapy to a given spatial region of the heart, the another time interval being one of during or after the therapy is applied to the given spatial region of the heart.

19. The method of claim 18 , wherein the therapy comprises at least one of an electrical stimulation therapy, a radio frequency therapy and a thermal therapy.

20. The method of claim 18 , further comprising concurrently displaying a graphical map of the first surrogate estimate of electrical activity and the second surrogate estimate of electrical activity.

21. The method of claim 1 , further comprising:
accessing electrical data corresponding to electrical signals sensed from body surface electrodes, at least some of which are arranged for sensing electrical activity for the zone; and
generating a graphical map of a heart in the patient's body that includes a representation of electrical information for the region of interest based on the electrical data sensed for the zone.

22. The method of claim 21 , wherein multiple instances of the graphical map are generated based on the electrical data acquired at different times during application of a therapy.

23. The method of claim

Assignees

• Cardioinsight Technologies Inc

Inventors

• Jia Ping
• Ramanathan Charulatha
• Strom Maria
• George Brian P
• Bhetwal Lalita
• Wodlinger Harold
• Small Jonathan D

Classifications

• A61N1/365

  controlled by a physiological parameter, e.g. heart potential {(evoked response A61N1/371)} · CPC title

• A61B5/748

  Selection of a region of interest, e.g. using a graphics tablet · CPC title

• A61B2018/00839

  Bioelectrical parameters, e.g. ECG, EEG · CPC title

• A61B5/0036 Primary

  including treatment, e.g., using an implantable medical device, ablating, ventilating · CPC title

• A61B18/12

  by passing a current through the tissue to be heated, e.g. high-frequency current · CPC title