System and program for controlling liquid chromatograph

Patent metadata

Field	Value
Publication number	US-9546987-B2
Application number	US-201214233009-A
Country	US
Kind code	B2
Filing date	Jun 28, 2012
Priority date	Jul 15, 2011
Publication date	Jan 17, 2017
Grant date	Jan 17, 2017

Abstract

A liquid chromatograph control system for controlling an operation of a liquid chromatograph which uses a mobile phase composed of a mixture of solvents and which has the function of performing a gradient analysis while temporally changing the mixture ratio of the solvents. The system initially requests a user to set a basic gradient profile (Step S 12 ), and subsequently, to set the number of steps to change the mixture ratio of the mobile phase at the beginning and/or at the end of the gradient process as well as the amount of change in the mixture ratio per step (Step S 13 ). After that, based on the possible combinations of the mixture ratios of the mobile phase at the beginning and at the end of the gradient process computed from the contents of information entered in the previous steps, a plurality of gradient profiles corresponding to those combinations are created (Step S 14 ).

First claim

The invention claimed is:

1. A liquid chromatograph comprising:
a liquid-sending unit that changes a mixture ratio of a plurality of solvents composing a mobile phase; and
an analysis condition setting control unit configured to set an analysis condition for a plurality of gradient analyses and to control an operation of the plurality of gradient analyses, where the mixture ratio of the plurality of solvents composing the mobile phase are temporally changed in each of the plurality of gradient analyses and a combination of the mixture ratio at a starting point and the mixture ratio at an ending point of the gradient analysis is different between the plurality of gradient analyses, the analysis condition setting control unit configured to:
a) provide entry locations on a display screen for allowing a user to enter the mixture ratio at the starting point and the mixture ratio at the ending point and allowing a user to set a number of times of changing at least one of the mixture ratios at the starting point and the ending point as well as an amount of change per one operation of changing the mixture ratio at the starting point or the ending point;
b) determine target values by making combinations of possible values of the mixture ratio at the starting point and possible values of the mixture ratio at the ending point based on contents of information entered by the user, and
c) create a plurality of gradient profiles respectively corresponding the aforementioned combinations on the display screen; and
d) control the liquid-sending unit so as to sequentially perform the plurality of gradient analyses according to the plurality of gradient profiles.

2. The liquid chromatograph according to claim 1 , wherein the analysis condition control unit is further configured to:
e) store a result of each of the plurality of gradient analysis performed according to the plurality of gradient profiles in an individual data file; and
f) name the data file in such a manner that a file name of the data file containing a result of a gradient analysis includes at least one of following items of information: a name of a column used in the gradient analysis, a name of a solvent used in the gradient analysis, the mixture ratio at the starting point, and the mixture ratio at the ending point.

3. A non-transitory computer readable medium recording a program for setting an analysis condition for a plurality of gradient analyses and for controlling the operation of a liquid chromatograph having a liquid-sending unit that temporally changes a mixture ratio of a plurality of solvents composing a mobile phase, where the mixture ratio of the plurality of solvents composing the mobile phase are temporally changed in each of the plurality of gradient analyses and a combination of the mixture ratio at a starting point and the mixture ratio at an ending point of the gradient analysis is different between the plurality of gradient analyses, by the following method:
a) providing entry locations on a display for allowing a user to enter the mixture ratio at the starting point and the mixture ratio at the ending point of the same process;
b) allowing a user to set a number of times of changing at least one of the mixture ratios at the starting point and the ending point as well as an amount of change per one operation of changing the mixture ratio at the starting point or the ending point;
c) a gradient profile creating step including
determining target values by making combinations of possible values of the mixture ratio at the starting point and possible values of the mixture ratio at the ending point based on the contents of information entered through the mixture ratio entry step and the change entry step, and
creating a plurality of gradient profiles respectively corresponding to the aforementioned combinations on the display; and
d) a control step for controlling the liquid-sending unit so as to sequentially perform gradient analyses according to the plurality of gradient profiles.

Assignees

• Ohashi Hiroshi
• Yamaguchi Tadayuki
• Terada Hidetoshi
• Shimadzu Corp

Inventors

• Ohashi Hiroshi
• Yamaguchi Tadayuki
• Terada Hidetoshi

Classifications

• G01N30/34 Primary

  of fluid composition, e.g. gradient (G01N30/36 takes precedence) · CPC title

• G01N30/466

  with separation columns in parallel · CPC title