Array structures of containers

Patent metadata

Field	Value
Publication number	US-9545772-B2
Application number	US-201113806042-A
Country	US
Kind code	B2
Filing date	Jun 24, 2011
Priority date	Jun 24, 2010
Publication date	Jan 17, 2017
Grant date	Jan 17, 2017

Abstract

An array structure includes a plurality of containers arranged in a predetermined pattern. Each container of the plurality of containers has a maximum outer dimension that is less than about 1 cm, and each container of the plurality of containers has a substantially predetermined porosity.

First claim

We claim:

1. An array structure comprising;
a substrate having a surface with a plurality of recessed slots; and
a plurality of containers arranged in a predetermined pattern with respect to each other in at least some of said recessed slots of said substrate, each of the plurality of containers having a spherical or polyhedral shape,
wherein each container of said plurality of containers is attached to the substrate or to another container of said plurality of containers,
wherein each container of said plurality of containers has an enclosing structure defining a plurality of pores and has a maximum outer dimension that is less than about 1 mm,
wherein each container of said plurality of containers has a substantially predetermined porosity, and
wherein at least one pore of said plurality of pores is facing a direction that is non-coplanar with a plane defined by directions of at least two other of said plurality of pores such that said substantially predetermined porosity is a three-dimensional porosity.

2. An array structure according to claim 1 , wherein each container of said plurality of containers has a maximum outer dimension that is less than 1 mm and greater than 1 nm.

3. An array structure according to claim 1 , wherein each side of each container of said plurality of containers defines at least one pore of a predetermined dimension to provide said predetermined porosity.

4. An array structure according to claim 3 , wherein said at least one pore has an effective diameter of at least 0.5 nm and less than 1 mm.

5. An array structure according to claim 3 , wherein said at least one pore has an effective diameter that is smaller than a first molecular species such that said first molecular species will be blocked from passing through said at least one pore, and wherein said at least one pore has an effective diameter that is larger than a second species of molecules such that said second species of molecules can pass through said at least one pore.

6. An array structure according to claim 1 , wherein said plurality of containers are arranged along a two-dimensional surface of said substrate.

7. An array structure according to claim 1 , wherein said plurality of containers are arranged to form a three-dimensional array.

8. An array structure according to claim 1 , wherein said plurality of containers are arranged with a space of at least 1 nm between adjacent containers and less than 1 cm.

9. An array structure according to claim 1 , further comprising at least one of a liquid chemical, a protein, a polymer, a bacteria, a mammalian cell, or combinations thereof contained within each of said plurality of containers.

10. An array structure according to claim 1 , wherein said substrate is a rigid substrate.

11. An array structure according to claim 1 , wherein said substrate is a flexible substrate.

12. An array structure according to claim 11 , wherein said flexible substrate is at least one of a paper, polymer, or cloth substrate.

13. An array structure according to claim 1 , wherein said plurality of containers comprise containers that have sizes and porosities selected such that a liquid contained in each container will diffuse substantially at a predetermined rate into a surrounding medium, said array structure providing a dynamic visual image while in operation.

14. An array structure according to claim 1 , wherein said plurality of containers are self-folding containers.

15. An array structure according to claim 1 , wherein said plurality of containers are polymer containers.

16. An array structure according to claim 1 , wherein said plurality of containers are biodegradable containers.

17. An array structure according to claim 1 , wherein said plurality of containers comprises containers of different sizes.

18. A bio-artificial pancreas, comprising:
a substrate having a surface with a plurality of recessed slots; and
a plurality of porous containers attached to said substrate in said recessed slots, each container of said plurality of porous containers having an enclosing structure defining a plurality of pores,
wherein each of the plurality of porous containers has a spherical or polyhedral shape and a maximum outer dimension that is less than about 1 mm,
wherein said plurality of porous containers are constructed to have a size, shape and porosity such that said plurality of porous containers are suitable to contain pancreatic islet cells therein, allow insulin produced by said pancreatic islet cells to pass therethrough, and provide immuno-isolation for said pancreatic islet cells, and
wherein at least one pore of said plurality of pores is facing a direction that is non-coplanar with a plane defined by directions of at least two other of said plurality of pores such that said substantially predetermined porosity is a three-dimensional porosity.

19. A bio-artificial pancreas according to claim 18 , wherein the plurality of porous containers have pores that have an effective diameter between 0.5 nm and 1 μm.

20. A bio-artificial pancreas according to claim 18 , where the substrate and the plurality of porous containers are configured to be implantable in a body of a patient.

21. A dynamic display device, comprising:
a substrate having a surface with a plurality of recessed slots; and
a plurality of containers attached to said substrate in a predetermined pattern in said recessed slots, each container of said plurality of containers having an enclosing structure defining a plurality of pores,
wherein each of the plurality of porous containers has a spherical or polyhedral shape and a maximum outer dimension that is less than about 1 mm,
wherein each container has a size, shape and porosity to allow a liquid to diffuse therefrom with a predetermined diffusion pattern as a function of time when said plurality of containers are immersed in a diffusion medium while in use, and
wherein at least one pore of said plurality of pores is facing a direction that is non-coplanar with a plane defined by directions of at least two other of said plurality of pores such that said substantially predetermined porosity is a three-dimensional porosity.

Assignees

• Gracias David H
• Kalinin Yevgeniy Vladimirovich
• Randall Christina Lee
• Univ Johns Hopkins

Inventors

• Gracias David H
• Kalinin Yevgeniy Vladimirovich
• Randall Christina Lee

Classifications

• Y10T428/268

  Monolayer with structurally defined element · CPC title

• B01L2300/0893

  having a very large number of wells, microfabricated wells · CPC title

• B81B7/0003

  MEMS mechanisms for assembling automatically hinged components, self-assembly devices (self-assembly processes B81C1/00007) · CPC title

• Y10T428/249971

  Preformed hollow element-containing · CPC title

• B01L2300/0819

  Microarrays; Biochips · CPC title