Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

Patent metadata

Field	Value
Publication number	US-9545457-B2
Application number	US-201414188598-A
Country	US
Kind code	B2
Filing date	Feb 24, 2014
Priority date	Jan 14, 1998
Publication date	Jan 17, 2017
Grant date	Jan 17, 2017

Abstract

The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.

First claim

What is claimed as new and desired to be secured by Letter Patent of United States is:

1. A method comprising
using an ultrasound contrast agent to enhance contrast in an echocardiographic ultrasound image of a subject, wherein the ultrasound contrast agent comprises
1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL;
sodium chloride;
glycerin, present in an amount of about 0.1 mL/mL;
propylene glycol, present in an amount of about 0.1 mL/mL;
water, and
perfluoropropane.

Assignees

• Lantheus Medical Imaging Inc

Inventors

• Hui Poh K
• Bishop John E
• Madrigal Jr Eleodoro S

Classifications

• A61K49/227

  Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric · CPC title

• A61B8/00

  Diagnosis using ultrasonic, sonic or infrasonic waves · CPC title

• A61K47/24

  containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids · CPC title

• A61K9/1277 Primary

  Preparation processes; Proliposomes · CPC title

• A61K49/226 Primary

  Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels · CPC title