Biomineral and metal binding liposomes, their synthesis, and methods of use thereof

Patent metadata

Field	Value
Publication number	US-9545452-B2
Application number	US-201113577131-A
Country	US
Kind code	B2
Filing date	Feb 7, 2011
Priority date	Feb 8, 2010
Publication date	Jan 17, 2017
Grant date	Jan 17, 2017

Abstract

Drug carriers, methods of synthesizing, and methods of use thereof are provided. The drug carriers are liposomes comprising at least one functionalized cholesterol of the formula: Chol-X-T, wherein X is a linker domain, T is at least one targeting moiety which binds hard tissue and/or medical implants, and Chol is cholesterol or a derivative or analog thereof. The liposomes may encapsulate at least one therapeutic agent for the treatment of an oral disease or disorder.

First claim

What is claimed is:

1. A liposome comprising at least one functionalized cholesterol of the formula: Chol-X-T, wherein X is a linker domain, T is at least one targeting moiety which binds hard tissue and/or medical implants, and Chol is cholesterol or a derivative or analog thereof,
wherein said liposome encapsulates at least one therapeutic agent for the treatment of an oral disease or disorder, and
wherein said functionalized cholesterol has the formula:

wherein n is 0 to about 10.

2. The liposome of claim 1 , wherein said targeting moiety is selected from the group consisting of bisphosphonates, alendronate, tetracycline, tetracycline analogs, sialic acid, malonic acid, N,N-dicarboxymethylamine, 4-aminosalicyclic acid, 5-aminosalicyclic acid, antibodies or fragments or derivatives thereof specific for hard tissue or implant material, and peptides comprising about 2 to about 100 amino acids selected from the group consisting of D-glutamic acid, L-glutamic acid, D-aspartic acid, L-aspartic acid, D-phosphoserine, L-phosphoserine, D-phosphothreonine, L-phosphothreonine, D-phosphotyrosine, and L-phosphotyrosine.

3. The liposome of claim 2 , wherein said targeting moiety is alendronate.

4. The liposome of claim 1 , wherein said functionalized cholesterol has the formula:

wherein n is 0 to about 10; wherein m is 1 to about 10; and q is 1 to about 10.

5. The liposome of claim 1 , wherein said liposome further encapsulates at least one detectable agent.

6. The liposome of claim 1 , wherein said therapeutic agent comprises fluoride.

7. A composition comprising at least one liposome of claim 1 and at least one pharmaceutically acceptable carrier.

8. A method of inhibiting a bone related disease or disorder and/or oral disease or disorder, said method comprising administering the composition of claim 7 to a subject.

9. The liposome of claim 1 , wherein said therapeutic agent is selected from the group consisting of menthol, a fragrant agent, a flavoring agent, cooling agent, fluoride, vitamins, neutraceuticals, tooth whitening agents, tooth coloring agents, bleaching or oxidizing agents, thickening agents, and sweetening agents.

Assignees

• Wang Dong
• Liu Xin-Ming
• Univ Nebraska

Inventors

• Wang Dong
• Liu Xin-Ming

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61K9/1271

  Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers (liposomes as conjugates {A61K47/6911}) · CPC title

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title

• A61K9/1272

  comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers (lipids as modifying agents {A61K47/543}) · CPC title