Method for activating a chemical reaction, solution that can be activated by said method and device for implementing said method

Patent metadata

Field	Value
Publication number	US-9545375-B2
Application number	US-201414759584-A
Country	US
Kind code	B2
Filing date	Jan 3, 2014
Priority date	Jan 8, 2013
Publication date	Jan 17, 2017
Grant date	Jan 17, 2017

Abstract

The invention relates to a method which comprises emitting ultrasound into a liquid mixture containing first and second reagents in separate phases initially separated by a liquid precursor-gas barrier, the ultrasound having a high enough energy level to vaporize the precursor gas, such as to contact the reagents and thus to activate a chemical reaction therebetween.

First claim

The invention claimed is:

1. A method for activating a chemical reaction in a solution forming a liquid mixture containing at least first and second reagents in distinct phases initially separated by at least one liquid gas-precursor barrier that can be vaporized by ultrasound, said method comprising an activation step wherein ultrasonic waves are emitted into the mixture, with an energy level sufficient to vaporize the gas precursor, thereby placing said reagents in contact with each other.

2. The method according to claim 1 , wherein the ultrasound is emitted in a localized manner in a medium containing the mixture, so as to activate the reaction between the reagents only within a given target area.

3. The method according to claim 1 , wherein said reagents are initially contained in an emulsion comprising, in an outer solution, drops comprising at least the first reagent and said gas precursor, these being encapsulated by at least one emulsifier.

4. The method according to claim 1 , wherein the reagents are initially contained in a microtube and separated by at least one drop of gas precursor, and said at least one drop of gas precursor is vaporized during the activation step.

5. A solution that can be activated by ultrasound, forming a liquid mixture containing at least first and second reagents in distinct phases separated by at least one liquid gas-precursor barrier that can be vaporized by ultrasound, said first and second reagents being adapted to react with one another.

6. The solution according to claim 5 , wherein the first and second reagents are contained in a microtube and are separated by at least one drop of gas precursor.

7. The solution according to claim 5 , wherein the first and second reagents are contained in an emulsion comprising, in an outer solution, drops comprising at least the first reagent and said gas precursor, these being encapsulated by at least one emulsifier.

8. The solution according to claim 7 , wherein said drops comprise a first outer emulsifier membrane and contain first primary drops containing the first reagent and second primary drops containing the second reagent, said first and second primary drops each being enclosed by a second emulsifier membrane and being in emulsion in the gas precursor.

9. The solution according to claim 7 , wherein said drops are distributed into first and second groups of drops, the drops of the first group containing the first reagent and the drops of the second group containing the second reagent.

10. The solution according to claim 9 , wherein said drops comprise a first outer emulsifier membrane and contain primary drops in emulsion in the gas precursor, said primary drops being enclosed by a second emulsifier membrane and containing either the first reagent or the second reagent.

11. The solution according to claim 7 , wherein the second reagent is contained in the outer solution.

12. A device for implementing a method according to claim 4 , comprising:
at least one microtube comprising a solution that can be activated by ultrasound, forming a liquid mixture containing at least first and second reagents in distinct phases separated by at least one liquid gas-precursor barrier that can be vaporized by ultrasound, said first and second reagents being adapted to react with each other, said liquid gas-precursor barrier comprising at least one drop of liquid gas-precursor,
at least one acoustic transducer suitable for emitting ultrasound toward the drop of gas precursor in order to vaporize it and thereby cause said first and second reagents to react with each other.

Assignees

• Centre Nat De La Rech Scient - Cnrs
• Ecole Supérieure De Physique Et Chimie Ind De La Ville De Paris
• Inserm - Inst Nat De La Santé Et De La Rech Médicale
• Centre Nat De La Rech Scientifique—Cnrs
• Ecole Superieure De Physique Et Chimie Ind De La Ville De Paris
• Inserm (Institut Nat De La Sante Et De La Rech Medicale)

Inventors

• Couture Olivier
• Tanter Mickael
• Tabeling Patrick
• Cossy Janine
• Fink Mathias

Classifications

• B01J2219/0888

  Liquid-liquid · CPC title

• B01J2219/0877

  Liquid · CPC title

• B01J2219/0875

  Gas · CPC title

• B01J2208/00716

  Means for reactor start-up · CPC title

• B01J19/0093

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title