Porous and nonporous materials for tissue grafting and repair

Patent metadata

Field	Value
Publication number	US-9545315-B2
Application number	US-201313905963-A
Country	US
Kind code	B2
Filing date	May 30, 2013
Priority date	Oct 25, 2005
Publication date	Jan 17, 2017
Grant date	Jan 17, 2017

Abstract

Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

First claim

What is claimed is:

1. A method for producing a three-dimensional porous scaffold comprising:
providing a plurality of resorbable particles;
compressing the particles together; and thereafter
bonding the particles together to form a scaffold.

2. A three-dimensional porous scaffold comprising compressed and bonded resorbable particles, made by the method of claim 1 .

3. The three-dimensional porous scaffold of claim 2 , wherein said scaffold is in a form selected from the group consisting of a granule, a sheet, a rod, and a block.

4. An implant comprising the three-dimensional porous scaffold of claim 2 , wherein the implant is selected from the group consisting of an interbody spacer, a fusion device and a bone graft.

5. A kit comprising
the three-dimensional scaffold of claim 2 ; and
at least one additional component selected from the group consisting of a device for placement or shaping of the scaffold in a patient, at least one device for visualizing the scaffold within a patient, and at least one material for adding biological activity to the scaffold.

6. A method of treating a patient comprising inserting into a patient an implant comprising the three-dimensional scaffold of claim 2 .

7. A three-dimensional scaffold comprising:
a plurality of mixed biodegradable particles having at least two different degradation rates;
wherein the particles are bound together to form a three-dimensional scaffold.

8. The three-dimensional scaffold of claim 7 , wherein said three-dimensional scaffold is in a form selected from the group consisting of a granule, a sheet, a rod, and a block.

9. An implant comprising the three-dimensional scaffold of claim 7 , wherein said implant is selected from the group consisting of an interbody spacer, a fusion device and a bone graft.

10. A kit comprising
the three-dimensional scaffold of claim 7 ; and
at least one additional component selected from the group consisting of a device for placement or shaping of the scaffold in a patient, at least one device for visualizing the scaffold within a patient, and at least one material for adding biological activity to the scaffold.

11. A method of treating a patient comprising inserting into a patient an implant comprising the three-dimensional scaffold of claim 7 .

12. A method for producing an elastomeric scaffold comprising:
providing a plurality of elastomeric particles; and
bonding the elastomeric particles together to form a porous or semi-porous elastomeric scaffold comprising said elastomeric particles.

13. The method of claim 12 , wherein said bonding is performed using at least one method selected from the group consisting of heat, solvents, adhesives, and polymer cross-linking.

14. The method of claim 12 , wherein said elastomeric particles comprise at least one material selected from the group consisting of silicone, hydrogels, and polyurethane.

15. The method of claim 12 , further comprising compressing the elastomeric particles together prior to bonding.

16. A porous or semi-porous, elastomeric scaffold made by the method of claim 12 , wherein said scaffold comprises bonded elastomeric particles.

17. The elastomeric scaffold of claim 16 , wherein said elastomeric particles comprise at least one material selected from the group consisting of silicone, hydrogels, and polyurethane.

18. An implant comprising at least one porous or semi-porous, elastomeric scaffold according to claim 16 , wherein the implant is adapted for at least one of nucleus or disk replacement, cartilage repair, and soft tissue augmentation.

19. A kit comprising
the porous or semi-porous, elastomeric scaffold claim 16 ; and
at least one additional component selected from the group consisting of a device for placement or shaping of the scaffold in a patient, at least one device for visualizing the scaffold within a patient, and at least one material for adding biological activity to the scaffold.

20. A method of treating a patient comprising inserting into a patient an implant comprising the porous or semi-porous, elastomeric scaffold of claim 16 .

Assignees

• Globus Medical Inc

Inventors

• Borden Mark

Classifications

• A61F2002/30032

  differing in absorbability or resorbability, i.e. in absorption or resorption time · CPC title

• Y10S606/907

  Composed of particular material or coated · CPC title

• A61F2002/30784

  Plurality of holes · CPC title

• A61F2/4455 Primary

  for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages (intervertebral discs A61F2/442) · CPC title

• A61F2/3094

  Designing or manufacturing processes · CPC title