Cell-Penetrating Peptide, Conjugate Comprising Same and Composition Comprising Same
US-2016151512-A1 · Jun 2, 2016 · US
US9540419B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9540419-B2 |
| Application number | US-201314400291-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 7, 2013 |
| Priority date | May 11, 2012 |
| Publication date | Jan 10, 2017 |
| Grant date | Jan 10, 2017 |
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A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating a variety of different types of inflammatory diseases.
Opening claim text (preview).
The invention claimed is: 1. A method for treating Alzheimer's disease comprising administering to a subject in need thereof a composition comprising the isolated peptide of SEQ ID NO: 1. 2. The method of claim 1 , wherein the composition is administered through oral, rectal, transdermal, intravenous, intramuscular, intraperitoneal, in the bone marrow, epidural, or subcutaneous means. 3. The method of claim 1 , wherein the composition comprises 0.1 μg/mg to 1 mg/mg of the isolated peptide. 4. The method according to claim 1 , wherein the peptide is administered in a single dose at a concentration of 0.1 μg/kg to 1.0 g/kg. 5. The method according to claim 1 , wherein the peptide is administered in a single dose at a concentration of 1 μg/kg to 10 mg/kg. 6. The method according to claim 1 , wherein the peptide is administered 1 to 3 times a day. 7. The method of claim 1 , wherein the peptide is administered at a daily dose of 0.1 μg/kg to 1.0 g/kg. 8. The method of claim 7 , wherein the peptide is administered 1 to 3 times daily.
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