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US-9735369-B2 · Aug 15, 2017 · US
Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
US9540327B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9540327-B2 |
| Application number | US-16071307-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 16, 2007 |
| Priority date | Jan 13, 2006 |
| Publication date | Jan 10, 2017 |
| Grant date | Jan 10, 2017 |
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Abstract
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Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
First claim
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We claim: 1. A bis-quaternary ammonium compound of Formula (I) X 2 ⊖⊕R 2 —R—R 1 ⊕⊖X 1 (I) wherein X 1⊖ and X 2⊖ are each independently an organic or inorganic anion; wherein R is selected from the group consisting of —(CH 2 ) 12 —; wherein R 1 and R 2 are each six membered rings as shown in formula (IIA), wherein each ring of R 1 and R 2 has one quaternized nitrogen atom, and the ring atoms from R 1 and R 2 which are attached to R cannot both be nitrogen atoms:…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
- C07D213/24Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9540327B2 cover?
- Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
- Who is the assignee on this patent?
- Crooks Peter, Dwoskin Linda P, Zheng Guangrong, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07D213/24. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 10 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).